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The paper is concerned with distributed learning in large-scale games. The well-known fictitious play (FP) algorithm is addressed, which, despite theoretical convergence results, might be impractical to implement in large-scale settings due to intense computation and communication requirements. An adaptation of the FP algorithm, designated as the empirical(More)
Amiloride (1), the prototypical epithelial sodium channel (ENaC) blocker, has been administered with limited success as aerosol therapy for improving pulmonary function in patients with the genetic disorder cystic fibrosis. This study was conducted to synthesize and identify more potent, less reversible ENaC blockers, targeted for aerosol therapy and(More)
—The paper concerns the development of distributed equilibria learning strategies in large-scale multi-agent games with repeated plays. With inter-agent information exchange being restricted to a preassigned communication graph, the paper presents a modified version of the fictitious play algorithm that relies only on local neighborhood information exchange(More)
The paper is concerned with learning in large-scale multi-agent games. The empirical centroid fictitious play (ECFP) algorithm is a variant of the well-known fictitious play algorithm that is practical and computationally tractable in large-scale games. ECFP has been shown to be an effective tool in learning consensus equilibria (a subset of the Nash(More)
This Letter describes a series of potent and selective BRS-3 agonists containing a biarylethylimidazole pharmacophore. Extensive SAR studies were carried out with different aryl substitutions. This work led to the identification of a compound 2-{2-[4-(pyridin-2-yl)phenyl]ethyl}-5-(2,2-dimethylbutyl)-1H-imidazole 9 with excellent binding affinity (IC(50)=18(More)
The paper is concerned with distributed learning and optimization in large-scale settings. The well-known Fictitious Play (FP) algorithm has been shown to achieve Nash equilibrium learning in certain classes of multi-agent games. However, FP can be computationally difficult to implement when the number of players is large. Sampled FP is a variant of FP that(More)
A fundamental problem with the Nash equilibrium concept is the existence of certain “structurally deficient” equilibria that (i) lack fundamental robustness properties, and (ii) are difficult to analyze. The notion of a “regular” Nash equilibrium was introduced by Harsanyi. Such equilibria are highly robust and relatively simple to analyze. A game is said(More)
The paper studies the highly prototypical Fictitious Play (FP) algorithm, as well as a broad class of learning processes based on best-response dynamics, that we refer to as FP-type algorithms. A well-known shortcoming of FP is that, while players may learn an equilibrium strategy in some abstract sense, there are no guarantees that the period-by-period(More)
SAR around non-peptidic potent bombesin receptor subtype-3 (BRS-3) agonist lead 2 is presented. Attempts to replace the carboxylic acid with heterocyclic isosteres to improve oral bioavailability and brain penetration are described.