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BACKGROUND Design of experiments (DOE) is a systematic approach to assess the effects of many factors on a response of an assay. This paper provides a case study whereby DOE was successfully utilized to evaluate robustness parameters for a ligand-binding assay (LBA). METHODOLOGY A 24-run Plackett-Burman design was developed to investigate factors that may(More)
A constant demand in the pharmaceutical industry is to accomplish more with the same or fewer resources. It is generally accepted that a major expense of an established laboratory is the personnel, which constitutes a fixed cost. Improving the efficiency of laboratory personnel through automation reduces the overall cost. In addition to this demand, there(More)
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