Brian S Palmer

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In this work, we present the first human magnetic resonance image (MRI) obtained at ultrahigh field strengths (8 T). We demonstrate that clinical imaging will be possible at 8 T and that reasonable quality head images can be obtained at this field strength. Most importantly, we emphasize that the power required to excite the spins at 8 T is much lower than(More)
Post-ischemic myocardial dysfunction has been observed in a variety of clinical situations including cardiac arrest. Potentially survivable cardiac arrest following short-term global myocardial ischemia may be of insufficient duration to cause irreversible myocyte injury, but still results in contractile and bioenergetic dysfunction. The purpose of this(More)
OBJECTIVE In this study, we test the hypothesis that a period of low flow perfusion before full reperfusion improves ventricular function and bioenergetics. DESIGN Prospective, randomized, controlled animal study. SETTING Research laboratory. SUBJECTS Sprague-Dawley rats. INTERVENTIONS Hearts were perfused with Krebs-Henseleit buffer at 85 mm Hg.(More)
Cardiac troponin I (cTnI) degradation has been noted in the stunned myocardium of rodents after ischemia and reperfusion and is one proposed mechanism for the decreased left ventricular (LV) contractility in postischemic hearts. cTnI degradation has been best described after reperfusion of the ischemic myocardium. The effect of ischemia, independent of(More)
OBJECTIVE To determine whether epinephrine in combination with high flow worsens left ventricular (LV) myocardial high-energy phosphate stores during reperfusion of ischemic ventricular fibrillation (VF). DESIGN Blinded, prospective block randomized, placebo controlled study. SETTING University medical center research laboratory. SUBJECTS A total of(More)
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