Brian S Comer

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Preclinical Research MicroRNA (miR)-155 and cyclooxygenase (COX)-2 are both elevated in numerous cancers including colorectal cancer. MiR-155 enhances COX-2 expression and is an established regulator of epithelial-mesenchymal transition and inflammation. Inhibition of miR-155 or COX-2 exhibit similar negative effects on tumorigenicity. Thus, it is(More)
Activation of vascular endothelial small- (KCa2.3, SK3) or intermediate- (KCa3.1, IK1) conductance Ca(2+)-activated potassium channels induces vasorelaxation via an endothelium-derived hyperpolarization (EDH) pathway. Although the activation of SK3 and IK1 channels converges on EDH, their subcellular effects on signal transduction are different and not(More)
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