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BACKGROUND Debate persists with regard to how best to categorize the syndromal dimension of negative symptoms in schizophrenia. The aim was to first review published Principle Components Analysis (PCA) of the PANSS, and extract items most frequently included in the negative domain, and secondly, to examine the quality of items using Item Response Theory(More)
OBJECTIVE An accurate computable representation of food and drug allergy is essential for safe healthcare. Our goal was to develop a high-performance, easily maintained algorithm to identify medication and food allergies and sensitivities from unstructured allergy entries in electronic health record (EHR) systems. MATERIALS AND METHODS An algorithm was(More)
PURPOSE We describe the decision drivers, development and implementation of an integrated mobile situational awareness application for the perioperative environment. This digital operating room tool for anesthesiologists facilitates direct supervision of in-room staff without requiring being tied to a stationary computer workstation. METHODS The iOS(More)
BACKGROUND Considering the increasing attention to the study of failed clinical trials, the goal of this study was to identify the sources of unreliability in a failed clinical trial by assessing scores on the Positive and Negative Syndrome Scale (PANSS). METHODS This study is a substudy from a failed phase 2 double-blind, placebo-controlled trial of(More)
BACKGROUND Considering the scarcity of longitudinal assessments of reliability, there is need for a more precise understanding of cognitive decline in Alzheimer's Disease (AD). The primary goal was to assess longitudinal changes in inter-rater reliability, test retest reliability and internal consistency of scores of the ADAS-Cog. METHODS 2,618 AD(More)
BACKGROUND The objective of this study was to examine the cross-cultural differences of the PANSS across six geo-cultural regions. The specific aims are (1) to examine measurement properties of the PANSS; and (2) to examine how each of the 30 items function across geo-cultural regions. METHODS Data was obtained for 1,169 raters from 6 different regions:(More)
Obstructive sleep apnea (OSA) is a disorder characterized by periods of breathing cessation during sleep caused by an airway obstruction. Decreased oxygen levels in the blood caused by this disorder can lead to brain and heart damage. Patients suffering from sleep apnea are especially susceptible to damage in the 48 hours post-anesthesia. In this study, we(More)
It has been reported that peripheral blood lymphocytes from patients with multiple sclerosis (MS) adhere to measles-infected human epithelial cells in significantly greater numbers than do lymphocytes from healthy volunteers or patients with other neurologic diseases. We have confirmed this observation in three separate studies, and have investigated the(More)