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The genomic basis of adaptive evolution in threespine sticklebacks
TLDR
A high-quality reference genome assembly for threespine stickleback fish is developed and it is indicated that reuse of globally shared standing genetic variation has an important role in repeated evolution of distinct marine and freshwater sticklebacks, and in the maintenance of divergent ecotypes during early stages of reproductive isolation. Expand
THE GENETICS OF ADAPTIVE SHAPE SHIFT IN STICKLEBACK: PLEIOTROPY AND EFFECT SIZE
TLDR
A quantitative trait loci study of a suite of 54 position traits describing body shapes of two threespine stickleback species suggested that sex differences may provide variation upon which selection can act, consistent with predictions of the geometric model of adaptation. Expand
The Genetic Architecture of Skeletal Convergence and Sex Determination in Ninespine Sticklebacks
TLDR
This research highlights the need to understand more fully the evolutionary drivers of infectious disease and how these drivers can be influenced by environmental factors. Expand
The Genetic Architecture of Skeletal Convergence and Sex Determination in Ninespine Sticklebacks
TLDR
The first genome-wide linkage map for ninespine sticklebacks is generated and quantitative trait locus mapping is used to identify chromosome regions controlling several skeletal traits and sex determination and to generate an exciting opportunity to study the mechanisms controlling similar phenotypic changes in different animal groups. Expand
Modular Skeletal Evolution in Sticklebacks Is Controlled by Additive and Clustered Quantitative Trait Loci
Understanding the genetic architecture of evolutionary change remains a long-standing goal in biology. In vertebrates, skeletal evolution has contributed greatly to adaptation in body form andExpand
A recurrent regulatory change underlying altered expression and Wnt response of the stickleback armor plates gene EDA
TLDR
Parallel evolution of low-plated sticklebacks has occurred through a shared DNA regulatory change, which reduces the sensitivity of an EDA enhancer to Wnt signaling, and alters expression in developing armor plates while preserving expression in other tissues. Expand
The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate.
TLDR
It is found that ntl function is required to repress medial floor plate and promote notchord fate in cells of the wild-type notochord domain and that spt and ntl together are required non cell-autonomously for medial floor Plate formation, suggesting that an inducing signal present in wild- type mesoderm is lacking in spt(-);ntl(-) embryos. Expand
GENETIC SIGNATURE OF ADAPTIVE PEAK SHIFT IN THREESPINE STICKLEBACK
TLDR
The results suggest that a series of adaptive improvements to a new environment leaves a detectable mark in the genome of wild populations, and the prediction may be robust enough to the complexities of natural environments to be useful when forecasting adaptive responses to large environmental changes. Expand
A Simple and Efficient Microinjection Protocol for Making Transgenic Sticklebacks
TLDR
This work has tested a variety of methods for microinjection of DNA into 1-2 cell stickleback embryos and injected a DNA plasmid containing the zebrafish muscle specific (α) actin promoter fused to the coding region of a jellyfish green fluorescent protein (GFP) gene, together with the rare cutting endonuclease, ISceI. Expand
Dorsal spine evolution in threespine sticklebacks via a splicing change in MSX2A
TLDR
MSX2A is a major gene underlying dorsal spine reduction in freshwater sticklebacks, linked to a separate gene controlling bony plate loss, helping explain the concerted effects of chromosome 4 on multiple armor-reduction traits. Expand
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