Brian R. Berry

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BACKGROUND Non-Hodgkin lymphomas are a heterogeneous group of solid tumours that constitute the 5(th) highest cause of cancer mortality in the United States and Canada. Poor control of cell death in lymphocytes can lead to autoimmune disease or cancer, making genes involved in programmed cell death of lymphocytes logical candidate genes for lymphoma(More)
Non-Hodgkin lymphomas (NHL) are a heterogeneous group of solid tumours of lymphoid cell origin. Three important aspects of lymphocyte development include immunity and inflammation, DNA repair, and programmed cell death. We have used a previously established case-control study of NHL to ask whether genetic variation in genes involved in these three important(More)
The role of fashion and fatshion blogging in college women's negotiation of identity." MA (Master of Arts) thesis, iv ACKNOWLEDGMENTS First, I would never have made it through this journey without my wonderful advisor, Gigi Durham. I am fully indebted to your consistent edits, advice, and guidance throughout this entire process and my time in graduate(More)
BACKGROUND Small lymphocytic lymphoma is a relatively rare B-cell non-Hodgkin lymphoma that is considered to be the tissue equivalent of the much more common entity chronic lymphocytic leukemia. Cutaneous manifestations of small lymphocytic lymphoma are infrequent and the literature regarding them sparse. We describe here a case of a patient with a history(More)
The anaplastic lymphoma kinase (ALK) gene encodes a receptor tyrosine kinase, which was first identified as the fusion partner of the nucleophosmin (NPM1) gene in the recurrent t(2;5)(p23;q35) found in a subset of anaplastic large cell lymphoma (ALCL). Several distinct, non-NPM1, ALK fusions have subsequently been described in lymphomas and other tumor(More)
A fundamental challenge in cancer genomics is to design effective, personalized treatments based on the mutational profiles of tumors. Pharmacological targeting of the numerous aberrant pathways found in individual tumors remains exceedingly challenging, but T cell-based therapies are an attractive alternative because of the enormous diversity and exquisite(More)
H2AFX encodes a histone variant involved in signaling sites of DNA damage and recruiting repair factors. Genetic variants in H2AFX may influence risk of non-Hodgkin lymphoma (NHL), a heterogeneous group of lymphoid tumors that are characterized by chromosomal translocations. We previously reported that rs2509049, a common variant in the promoter of H2AFX,(More)
it is " perhaps the seminal text of the spatial-quantitative revolution. Certainly in terms of laying out the philosophical presuppositions of that movement it had no peer. " (p71) But Cox goes further: " It was also the spatial-quantitative revolution that gave impetus to conceptual precision in the field … it was the prospect of measurement, of(More)
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