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Transcriptional elongation requires DNA break-induced signalling
- Heeyoun Bunch, Brian P. Lawney, +5 authors S. Calderwood
- Medicine, Biology
- Nature communications
- 16 December 2015
It is proposed that DDR signalling is required for effective Pol II pause release and transcriptional elongation through a novel mechanism involving TRIM28, DNA-PK and topoisomerase II. Expand
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer
- G. Zadra, Caroline F. Ribeiro, +29 authors M. Loda
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 21 December 2018
It is demonstrated that selective FASN inhibition antagonizes CRPC growth through metabolic reprogramming and results in reduced protein expression and transcriptional activity of both full-length AR (AR-FL) and AR-V7, which offers a therapeutic opportunity for mCRPC and a potential mechanism to overcome resistance to AR inhibitors. Expand
Frequency filtering in disordered granular chains
The study of disorder-induced frequency filtering is presented for one-dimensional systems composed of random, pre-stressed masses interacting through both linear and nonlinear (Hertzian) repulsive… Expand
MicroRNA-mRNA networks define translatable molecular outcome phenotypes in osteosarcoma
The results support the existence of molecularly defined phenotypes in osteosarcoma associated with distinct outcome independent of clinicopathologic features and may define previously unrecognized osteosARcoma subtypes with distinct molecular context and clinical course potentially appropriate for future application of tailored treatment strategies in different patient subgroups. Expand
RNA polymerase II promoter-proximal pausing in mammalian long non-coding genes.
The genomic study has shown that a significant number of long non-coding RNAs (lncRNAs, >1000 nucleotides) harbor RNA polymerase II (Pol II) engaged with the transcriptional start site, suggesting an important role of Pol II pausing for the transcription of mammalian lncRNA genes. Expand
Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors.
Using whole transcriptome shotgun sequencing after PAX8 knockdown and ChIP-Seq, it is shown that FTSECs and HGSOCs are distinguished by marked reprogramming of the PAX8 cistrome, and transcriptional changes after transformation in ovarian cancer are closely related to epigenetic remodeling in lineage-specific transcription factors. Expand
Allosterically coupled multi-site binding of testosterone to human serum albumin.
Molecular dynamics studies revealed that testosterone's binding to fatty acid binding site 3 on HSA was associated with conformational changes at site 6, indicating that residues in in these two distinct binding sites are allosterically coupled. Expand
Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states
Contrary to the prevalent view, it is shown that estradiol's binding to SHBG is nonlinear, and the "apparent" Kd changes with varying Estradiol and SHBG concentrations. Expand
Constitutive Ras signaling and Ink4a/Arf inactivation cooperate during the development of B-ALL in mice.
E engineered mouse strains with induced somatic KrasG12D pathway activation and/or loss of Ink4a/Arf during early stages of B-cell development induced a fully penetrant, highly aggressive B-all phenotype resembling high-risk subtypes of human B-ALL such as BCR-ABL and CRFL2-rearranged. Expand
Transcriptional Elongation Requires DNA Double Stand Break and Repair