Brian P. Kelly

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CD4 T cells are both necessary and sufficient to mediate acute cardiac allograft rejection in mice. This process requires "direct" engagement of donor MHC class II molecules. That is, acute rejection by CD4+ T cells requires target MHC class II expression by the donor and not by the host. However, it is unclear whether CD4+ T cell rejection requires MHC(More)
Recent studies using mouse models demonstrate that CD4(+) T cells are sufficient to mediate acute cardiac allograft rejection in the absence of CD8(+) T cells and B cells. However, the mechanistic basis of CD4-mediated rejection is unclear. One potential mechanism of CD4-mediated rejection is via elaboration of proinflammatory cytokines such as IFN-gamma.(More)
STUDY DESIGN A biomechanical testing protocol was used to study different lumbo-pelvic fixation techniques in a human cadaveric lumbar spine model. OBJECTIVE To compare the in vitro biomechanics of a novel four-rod lumbo-pelvic reconstruction technique with and with out cross-links, to that of a conventional cross-linked two-rod technique. SUMMARY OF(More)
Robotic methods applied to in-vitro biomechanical testing potentially offer more comprehensive evaluations however, standard position control algorithms make real-time load control problematic. This paper describes and evaluates a novel custom developed Cartesian force controlled biomechanical testing system with coordinated 6 degree of freedom (DOF)(More)
and to my wife, Mi Kyung Ye for their love and support. iii ACKNOWLEGEMENTS I would like to thank my advisor, Dr. Denis J. DiAngelo for giving me the opportunity to work on this project and for encouragement and guidance. I would also like to express my gratitude to other committee members, Dr. I also would like to gratefully acknowledge the care and(More)
OBJECTIVES Constitutional delay in growth and adolescence (CDGA) is common in boys, some of whom request treatment to accelerate growth and attainment of secondary sexual characteristics. The aims of this study were to confirm that a 3-month course of intramuscular testosterone oenanthate does not impair final height in boys with CDGA, and to determine the(More)
Angled screw insertion has been advocated to enhance fixation strength during posterior spine fixation. Stresses on a pedicle screw and surrounding vertebral bone with different screw angles were studied by finite element analysis during simulated multidirectional loading. Correlations between screw-specific vertebral geometric parameters and stresses were(More)
STUDY DESIGN A biomechanical testing protocol was used to study atlantoaxial fixation techniques in a human cadaveric model. OBJECTIVE To compare the in vitro biomechanics of locking plate fixation of the posterior arch of C1 to C2 laminar screw fixation, with that of conventional C1 lateral mass to C2 pars screw fixation. SUMMARY OF BACKGROUND DATA(More)
BACKGROUND Fusion of the talonavicular (TN) joint is an effective treatment for hindfoot pain and deformity. Nonunion in hindfoot fusion procedures is most common in the TN joint. The purpose of this study was to evaluate and compare the mechanical stability of 2 different forms of fixation for isolated fusion of the TN joint. MATERIALS AND METHODS 13(More)