Brian P Gregson

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We explored the feasibility and toxicity of administering escalating doses of anti-CD3/CD28 ex vivo costimulated T cells as a therapeutic adjunct for patients with relapsed, refractory, or chemotherapy-resistant, aggressive non-Hodgkin lymphoma (NHL) following high-dose chemotherapy and CD34+-selected hematopoietic cell transplantation (HCT). Sixteen(More)
Signals generated by T cell receptor (TCR) and CD28 engagement are required for optimal T cell activation, but how these signals integrate within the cell is still largely unknown. We have used near genome-scale expression profiling to monitor T cell signal transduction pathways triggered via TCR and/or costimulatory receptors. Ligation of CD28 alone(More)
The development of a simplified assay for detection of congeners of the microcystin (MC) hepatotoxin is described that combines the extreme sensitivity of surface-enhanced laser desorption/ionization time-of-flight MS (SELDI TOF-MS) with the superior selectivity of immunoaffinity interactions. Using methods similar to those of conventional immunoassays, MC(More)
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