Brian O'Donovan

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OBJECTIVE Identification of a particular cause of meningoencephalitis can be challenging owing to the myriad bacteria, viruses, fungi, and parasites that can produce overlapping clinical phenotypes, frequently delaying diagnosis and therapy. Metagenomic deep sequencing (MDS) approaches to infectious disease diagnostics are known for their ability to(More)
Existing methods for injecting reagents into drops utilize metal electrodes integrated into the microfluidic chip, adding cumbersome and error-prone steps to the fabrication process. Here, we introduce a method that uses the injection fluid itself as an electrode by exploiting dissolved electrolytes in the solution. This obviates the need for metal(More)
The improvement of business processes has recently emerged as one of the top business priorities for IT, and Business Process Management (BPM) is currently being seen as the best way to deliver process improvements. This research explores the enablers of BPM success, expanding on the Rosemann, de Bruin and Power theoretical BPM success model [1].(More)
Existing methods for picoinjecting reagents into microfluidic drops require metal electrodes integrated into the microfluidic chip. The integration of these electrodes adds cumbersome and error-prone steps to the device fabrication process. We have developed a technique that obviates the needs for metal electrodes during picoinjection. Instead, it uses the(More)
Here we study numerically the structure of directed state transition graphs for several types of finite-state devices representing morphology of 16 languages. In all numerical experiments we have found that the distribution of incoming and outcoming links is highly skewed and is modelled well by the power law, not by the Poisson distribution typical for(More)