Brian O’ Connell

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BACKGROUND Genital melanotic macules are poorly recognized lesions, which appear as isolated discrete macules. Their occurrence, usually as new pigmented lesions in adult life, can cause concern because they can mimic early melanoma. OBJECTIVE Our purpose was to define the clinical, histologic, immunohistochemical, and electronmicroscopic features of(More)
INTRODUCTION The occurrence of severe sepsis may be associated with deficient pro-inflammatory cytokine production. Transforming growth factor beta-1 (TGFbeta-1) predominantly inhibits inflammation and may simultaneously promote IL-17 production. Interleukin-17 (IL-17) is a recently described pro-inflammatory cytokine, which may be important in(More)
Bacterial orbital cellulitis is a condition that rarely presents with complete loss of vision. A case is reported of a 69-year-old man who presented with fulminant onset of proptosis, significant ophthalmoplegia and no perception of light. Computed tomography showed no evidence of paranasal sinus disease. Despite treatment with intravenous flucloxacillin,(More)
26 Linezolid is often the drug of last resort for serious methicillin-resistant Staphylococcus aureus 27 (MRSA) infections. Linezolid resistance is mediated by mutations in 23S rRNA and genes for 28 ribosomal proteins, cfr encoding phenicol, lincosamide, oxazolidinone, pleuromutilin and 29 streptogramin A (PhLOPS A) resistance, its homolgue cfr(B) or optrA(More)
submission for Research Papers, Industry Papers, and Industry Experience Reports February 1, 2013 Research Paper, Industry Paper, and Industry Experience Report submission February 8, 2013 Tutorial Proposal submission March 15, 2013 Grand Challenge Solu on with Paper submission April 12, 2013 Author no fica on for Research Papers, Industry Papers, Industry(More)
Treponematosis is a syndrome of chronic infectious diseases. There has been much debate on its origins and spread, particularly with regard to venereal syphilis, an unsightly and debilitating disease in preantibiotic populations. The osteological analysis of 5,387 individuals excavated by Museum of London Archaeology from the medieval burial ground of St.(More)
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