Brian Meenan

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Healthcare resource planners need to develop policies that ensure optimal allocation of scarce healthcare resources. This goal can be achieved by forecasting daily resource requirements for a given admission policy. If resources are limited, admission should be scheduled according to the resource availability. Such resource availability or demand can change(More)
Clinical investigators, health professionals and managers are often interested in developing criteria for clustering patients into clinically meaningful groups according to their expected length of stay. In this paper, we propose two novel types of survival trees; phase-type survival trees and mixed distribution survival trees, which extend previous work on(More)
The differentiation of stem cells into multi-lineages is essential to aid the development of tissue engineered materials that replicate the functionality of their tissue of origin. For this study, Raman spectroscopy was used to monitor the formation of a bone-like apatite mineral during the differentiation of human mesenchymal stem cells (hMSCs) towards an(More)
The ability to engineer biomaterial surfaces that are capable of a dynamic interaction with cells and tissues is central to the development of medical implants with improved functionality. An important consideration in this regard is the role played by the extracellular proteins that bind to an implant surface in vivo. Deliberate use of an ad-layer of such(More)
Characterisation of the electrostatic properties of dental enamel is important for understanding the interfacial processes that occur on a tooth surface and how these relate to the natural ability of our teeth to withstand chemical attack from the acids in many soft drinks. Whereas, the role of the mineral component of the tooth enamel in providing this(More)
In our previous work we proposed a phase type survival tree method for clustering patients into clinically meaningful patient groups. We also discussed its extension which uses the survival tree based analysis for patient pathway prognostication and to examine the relationship between length of stay in hospital and destination on discharge. The current(More)
Recent advances in areas such as biomarker discovery and microfluidic device fabrication have allowed clinical testing to be moved ever closer to the site of patient care. The development of a range of point-of-care testing (POCT) devices that seek to provide the clinician with diagnostic test results more rapidly offer the opportunity to enhance the(More)
Raman spectroscopy has been used to determine the chemical composition of materials for over 70 years. Recent spectacular advances in laser and CCD camera technology creating instruments with higher sensitivity and lower cost have initiated a strong resurgence in the technique, ranging from fundamental research to process control methodology. One such area(More)