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In response to pressure exerted by major histocompatibility complex (MHC) class I-mediated CD8(+) T cell control, human immunodeficiency virus (HIV) escape mutations often arise in immunodominant epitopes recognized by MHC class I alleles. While the current standard of care for HIV-infected patients is treatment with highly active antiretroviral therapy(More)
In this study we examine the relationship between a woman's social contexts at the time of diagnosis and her chances of having survived breast cancer four years later. A cohort of 133 women were followed prospectively after initial diagnosis and treatment and data were obtained from a questionnaire mailed soon after diagnosis and from hospital charts. Using(More)
We propose a complete system for lifelogging where audio is continuously recorded using a smartphone or a wearable recorder. Recorded audio includes speech, music and environmental sounds. First, we describe a feature-based segmentation algorithm for breaking down a long piece of audio into smaller clips. In order to archive clips into a large database, we(More)
MicroRNAs (miRNAs) have been implicated in DNA repair pathways through transcriptional responses to DNA damaging agents or through predicted miRNA regulation of DNA repair genes. We hypothesized that additional DNA damage regulating miRNAs could be identified by screening a library of 810 miRNA mimetics for the ability to alter cellular sensitivity to(More)
Virtual platforms are widely used for system-level modeling, design and simulation. In this paper, we propose a virtual platform-based, top-down, system-level design methodology for developing and testing hardware/software right from the concept level and even before the architecture is finalized. The methodology is based on using tools such as QEMU,(More)
The Androgen Receptor (AR) plays a key role in prostate biology and in the progression of prostate cancer (PCa) to castration resistance. The role of microRNAs (miRNAs) in aberrant AR signaling have not been fully characterized. Here we screened a library of 810 miRNA mimics to identify miRNAs that alter AR activity in complementary functional assays(More)
Virtual platforms are widely used for system-level modeling, design and simulation. In this paper, we propose a virtual platform-based, top-down, system-level design methodology for developing and testing hardware/software right from the concept level and even before the architecture is finalized. The methodology is based on using tools such as QEMU,(More)
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