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Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial.

• Stephen M Davis, Geoffrey Alan Donnan, +18 authors Patricia M. Desmond
• The Lancet. Neurology
• 2008

BACKGROUND Whether intravenous tissue plasminogen activator (alteplase) is effective beyond 3 h after onset of acute ischaemic stroke is unclear. We aimed to test whether alteplase given 3-6 h after… (More)

Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome.

• Tracey A Baird, Mark William Parsons, +6 authors Stephen M Davis
• Stroke
• 2003

BACKGROUND AND PURPOSE Hyperglycemia at the time of ischemic stroke is associated with increased mortality and morbidity. Animal studies suggest that infarct expansion may be responsible. The… (More)

Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke.

• Mark William Parsons, P Alan Barber, +8 authors Stephen M Davis
• Annals of neurology
• 2002

Diffusion- and perfusion-weighted magnetic resonance imaging provides important pathophysiological information in acute brain ischemia. We performed a prospective study in 19 sub-6-hour stroke… (More)

Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study.

• Mark William Parsons, P Alan Barber, +5 authors Stephen M Davis
• Annals of neurology
• 2002

Controversy exists whether acute hyperglycemia is causally associated with worse stroke outcome or simply reflects a more severe stroke. In reversible ischemia models, hyperglycemia is associated… (More)

Perihematomal edema in primary intracerebral hemorrhage is plasma derived.

• Kenneth Scott A. Butcher, T Regan Baird, Lachlan MacGregor, Patricia M. Desmond, Brian M. Tress, Stephen Davis
• Stroke
• 2004

BACKGROUND AND PURPOSE The mechanisms of perihematomal injury in primary intracerebral hemorrhage (ICH) are incompletely understood. An MRI study was designed to elucidate the nature of edema and… (More)

Density and shape as CT predictors of intracerebral hemorrhage growth.

• Christen D Barras, Brian M. Tress, +9 authors Stephen M Davis
• Stroke
• 2009

BACKGROUND AND PURPOSE Intracerebral hemorrhage (ICH) growth predicts mortality and functional outcome. We hypothesized that irregular hematoma shape and density heterogeneity, reflecting active,… (More)

Failure of collateral blood flow is associated with infarct growth in ischemic stroke.

• Bruce C. V. Campbell, Søren Christensen, +8 authors Stephen M Davis
• Journal of cerebral blood flow and metabolism…
• 2013

Changes in collateral blood flow, which sustains brain viability distal to arterial occlusion, may impact infarct evolution but have not previously been demonstrated in humans. We correlated… (More)

Rapid assessment of perfusion-diffusion mismatch.

• Kenneth Scott A. Butcher, Mark Parsons, +5 authors Stephen M Davis
• Stroke
• 2008

BACKGROUND AND PURPOSE For MR perfusion-diffusion (PWI-DWI) mismatch to become routine in thrombolysis patient selection, rapid and reliable assessment tools are required. We examined interrater… (More)

Clinical-diffusion mismatch predicts the putative penumbra with high specificity.

• Jane Prosser, Ken J Butcher, +5 authors Stephen Davis
• Stroke
• 2005

BACKGROUND AND PURPOSE Perfusion-diffusion (PWI-DWI) mismatch may represent the ischemic penumbra. The complexities associated with perfusion-weighted imaging (PWI) have restricted its use. Mismatch… (More)

Apparent diffusion coefficient thresholds do not predict the response to acute stroke thrombolysis.

• Poh-Sien Loh, Kenneth Scott A. Butcher, +4 authors Stephen M Davis
• Stroke
• 2005

BACKGROUND AND PURPOSE Apparent diffusion coefficient (ADC) thresholds for tissue infarction have been identified in acute stroke. IV tissue plasminogen activator (tPA) is associated with tissue… (More)

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