Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical.

• Y. H. Ding, Brian M. Baker, David N. Garboczi, William E. Biddison, Don C. Wiley
• Immunity
• 1999

The interactions of three singly substituted peptide variants of the HTLV-1 Tax peptide bound to HLA-A2 with the A6 T cell receptor have been studied using T cell assays, kinetic and thermodynamic… (More)

Dissecting the energetics of a protein-protein interaction: the binding of ovomucoid third domain to elastase.

• Brian M. Baker, Kenneth P. Murphy
• Journal of molecular biology
• 1997

An understanding of the structural basis for protein-protein interactions, and molecular recognition in general, requires complete characterization of binding energetics. Not only does this include… (More)

TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms.

• Oleg Ya Borbulevych, Sujatha M. Santhanagopolan, Moushumi Hossain, Brian M. Baker
• Journal of immunology
• 2011

T cells engineered to express TCRs specific for tumor Ags can drive cancer regression. The first TCRs used in cancer gene therapy, DMF4 and DMF5, recognize two structurally distinct peptide epitopes… (More)

Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes

• Kathryn M. Armstrong, Kurt H. Piepenbrink, Brian M. Baker
• The Biochemical journal
• 2008

A necessary feature of the immune system, TCR (T-cell receptor) cross-reactivity has been implicated in numerous autoimmune pathologies and is an underlying cause of transplant rejection. Early… (More)

Identification of a Crucial Energetic Footprint on the α1 Helix of Human Histocompatibility Leukocyte Antigen (Hla)-A2 That Provides Functional Interactions for Recognition by Tax…

• Brian M. Baker, Richard V. Turner, Susan J. Gagnon, Don C. Wiley, William E. Biddison
• The Journal of experimental medicine
• 2001

Structural studies have shown that class I major histocompatibility complex (MHC)-restricted peptide-specific T cell receptor (TCR)-alpha/betas make multiple contacts with the alpha1 and alpha2… (More)

Evaluation of linked protonation effects in protein binding reactions using isothermal titration calorimetry.

• Brian M. Baker, Kenneth P. Murphy
• Biophysical journal
• 1996

A theoretical development in the evaluation of proton linkage in protein binding reactions by isothermal titration calorimetry (ITC) is presented. For a system in which binding is linked to… (More)

The structure and stability of an HLA-A*0201/octameric tax peptide complex with an empty conserved peptide-N-terminal binding site.

• Amir Riyaz Khan, Brian M. Baker, Paritosh Ghosh, William E. Biddison, Don C. Wiley
• Journal of immunology
• 2000

The crystal structure of the human class I MHC molecule HLA-A2 complexed with of an octameric peptide, Tax8 (LFGYPVYV), from human T cell lymphotrophic virus-1 (HTLV-1) has been determined. This… (More)

Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand.

• Rebecca L. Davis-Harrison, Kathryn M. Armstrong, Brian M. Baker
• Journal of molecular biology
• 2005

A6 and B7 are two alphabeta T cell receptors (TCRs) that recognize the Tax peptide presented by the class I major histocompatibility molecule HLA-A2 (Tax/HLA-A2). Despite the fact that the two TCRs… (More)

Prediction of binding energetics from structure using empirical parameterization.

• Brian M. Baker, Kenneth P. Murphy
• Methods in enzymology
• 1998

We have presented an empirical method that can be used to predict the binding energetics for protein-protein or protein-peptide interactions from three-dimensional structures. The approach differs… (More)

Cutting edge: Evidence for a dynamically driven T cell signaling mechanism.

• William F Hawse, Matthew M. Champion, +6 authors Brian M. Baker
• Journal of immunology
• 2012

T cells use the αβ TCR to bind peptides presented by MHC proteins (pMHC) on APCs. Formation of a TCR-pMHC complex initiates T cell signaling via a poorly understood process, potentially involving… (More)

• ‹
• 1
• 2
• 3
• 4
• 5
• ›