Brian Lewis

Vincent Seaman2
Paul Roda2
Ronald Hoffman2
2Vincent Seaman
2Paul Roda
2Ronald Hoffman
2Mingjiang Xu
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The Vanguard System#8482; is a Web-based collaborative modeling software for enterprise simulation and business planning. It supports proactive decision-making, resource optimization, and strategic planning using a number of novel capabilities including: enterprise simulation, collaborative modeling, a Wiki-style knowledge portal, and grid computing.(More)
BACKGROUND The role of the environment in the origin of polycythemia vera has not been well documented. Recently, molecular diagnostic tools have been developed to facilitate the diagnosis of polycythemia vera. A cluster of patients with polycythemia vera was suspected in three countries in eastern Pennsylvania where there have long been a concern about(More)
Memantine, an uncompetitive NMDA receptor antagonist used for the treatment of Alzheimer's disease (AD), has been hypothesized to have neuroprotective properties. However, the similarity of its mechanism of action to other NMDA receptor antagonists has led to concerns that it may also have neurotoxic effects. To assess both the neuroprotective and(More)
  • Michele L. Pearson, Joseph V. Selby, Kenneth A. Katz, Virginia Cantrell, Christopher R. Braden, Monica E. Parise +9 others
  • 2012
BACKGROUND Morgellons is a poorly characterized constellation of symptoms, with the primary manifestations involving the skin. We conducted an investigation of this unexplained dermopathy to characterize the clinical and epidemiologic features and explore potential etiologies. METHODS A descriptive study was conducted among persons at least 13 years of(More)
The arrival of electronic voting has generated considerable controversy, mostly about its vulnerability to fraud. By comparison, virtually no attention has been given to its usability, i.e., voters' ability to vote as they intend, which was central to the controversy surrounding the 2000 US presidential election. Yet it is hard to imagine a domain of(More)
  • Dongning Pan, Chunxiao Mao, Brian Quattrochi, Randall H Friedline, Lihua J Zhu, Dae Young Jung +3 others
  • 2014
Both classical brown adipocytes and brown-like beige adipocytes are considered as promising therapeutic targets for obesity; however, their development, relative importance and functional coordination are not well understood. Here we show that a modest expression of miR-378/378* in adipose tissue specifically increases classical brown fat (BAT) mass, but(More)
Cancer cluster investigations rarely receive significant public health resource allocations due to numerous inherent challenges and the limited success of past efforts. In 2008, a cluster of polycythemia vera, a rare blood cancer with unknown etiology, was identified in northeast Pennsylvania. A multidisciplinary group of federal and state agencies,(More)
Prostate cancer is the most common malignancy and the second leading cause of cancer death in men in the United States. Close to $12 billion are spent annually on the treatment of prostate cancer in the US alone. Yet still there remain tremendous controversies and challenges that exist in all facets of the disease. This review and discussion will focus on(More)
which permits the noncommercial use, distribution, and reproduction of the article in any medium, provided the original author and source are credited. You may not alter, transform, or build upon this article without the permission of the Author(s). For reprints and permission queries, please visit SAGE's Web site at Objectives: The purpose of this study(More)