Learn More
Studies over the past decade have enunciated silent synapses as prominent cellular substrates for synaptic plasticity in the developing brain. However, little is known about whether silent synapses can be generated postdevelopmentally. Here, we demonstrate that highly salient in vivo experience, such as exposure to cocaine, generates silent synapses in the(More)
Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens (NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of the two major mPFC-to-NAc projections differentially regulated the progressive increase in cue-induced cocaine seeking after withdrawal (incubation of cocaine craving).(More)
In this paper, we propose ICrafter, a framework for services and their user interfaces in a class of ubiquitous computing environments. The chief objective of ICrafter is to let users flexibly interact with the services in their environment using a variety of modalities and input devices. We extend existing service frameworks in three ways. First, to(More)
Through a study of field biology practices, we observed that biology fieldwork generates a wealth of heterogeneous information, requiring substantial labor to coordinate and distill. To manage this data, biologists leverage a diverse set of tools, organizing their effort in paper notebooks. These observations motivated ButterflyNet, a mobile capture and(More)
Parkinson's disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). An association has been reported between PD and exposure to mitochondrial toxins, including environmental pesticides paraquat, maneb, and rotenone. Here, using a robust, patient-derived stem cell model of PD allowing comparison of(More)
The nucleus accumbens (NAc) regulates motivated behavior by, in part, processing excitatory synaptic projections from several brain regions. Among these regions, the prefrontal cortex (PFC) and basolateral amygdala, convey executive control and affective states, respectively. Whereas glutamatergic synaptic transmission within the NAc has been recognized as(More)
On wall-size displays with pen or touch input, users can have difficulties reaching display contents located too high, too low, or too far away. Drag-and-drop interactions can be further complicated by bezels separating individual display units. Researchers have proposed a variety of interaction techniques to address this issue, such as extending the user's(More)
Cyanide is a life-threatening, bioterrorist agent, preventing cellular respiration by inhibiting cytochrome c oxidase, resulting in cardiopulmonary failure, hypoxic brain injury, and death within minutes. However, even after treatment with various antidotes to protect cytochrome oxidase, cyanide intoxication in humans can induce a delayed-onset neurological(More)
Visual signals generated by self-motion are initially represented in retinal coordinates in the early parts of the visual system. Because this information can be used by an observer to navigate through the environment, it must be transformed into body or world coordinates at later stations of the visual-motor pathway. Neurons in the dorsal aspect of the(More)