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In a previous paper the production of pneumonia in rabbits by the Meltzer method of intratracheal inoculation was reported (I). The results by this method have not been constant in the hands of all observers (2). An investigation of the details of the method was undertaken with the hope of determining the causes of this inconsistency. During the past two(More)
1. The production of lobar pneumonia in rabbits is dependent upon the introduction of organisms into the alveoli themselves. 2. In order to accomplish this the catheter through which they are injected must be inserted as deeply into a bronchus as possible and the culture fluid injected with considerable force. 3. Large numbers of organisms injected into the(More)