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Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer.
Cyclooxygenase (COX)-2 and its product prostaglandin (PG) E2 underlie an immunosuppressive network that is important in the pathogenesis of non-small cell lung cancer. CD4+ CD25+ T regulatory (Treg)Expand
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Intratumoral Administration of Dendritic Cells Overexpressing CCL21 Generates Systemic Antitumor Responses and Confers Tumor Immunity
To achieve in situ tumor antigen uptake and presentation, intratumoral administration of ex vivo-generated, gene-modified murine bone marrow-derived dendritic cells (DC) was used in a murine lungExpand
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IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis.
Based on studies by our group and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-gamma-dependent and independent manner. Here, we have evaluated the antifibroticExpand
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IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis
Based on studies by our group and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-γ–dependent and independent manner. Here, we have evaluated the antifibroticExpand
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IL-10 Mediates Sigma1 Receptor-Dependent Suppression of Antitumor Immunity1
Sigma receptors are unique endoplasmic reticulum proteins that mediate signaling for a variety of drugs. We determined the effect of sigma1 receptor agonists on immune responses in a syngeneic lungExpand
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Chemoprevention strategies with cyclooxygenase-2 inhibitors for lung cancer.
Clinical lung cancer is the ultimate event resulting from a series of genetic and epigenetic alterations in the respiratory epithelium at risk. According to the "field carcinogenesis" theory, theseExpand
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D-9-Tetrahydrocannabinol Inhibits Antitumor Immunity by a CB 2 Receptor-Mediated , Cytokine-Dependent Pathway 1
In this study, we show thatD-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, suppresses host immune reactivity against lung cancer. In two different weakly immunogenicExpand
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Cyclooxygenase 2 Inhibition Promotes IFN-γ-Dependent Enhancement of Antitumor Responses1
In previous studies, we demonstrated an immune suppressive network in non-small cell lung cancer that is due to overexpression of tumor cyclooxygenase 2 (COX-2). In this study, we assessed theExpand
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Cyclooxygenase 2 inhibition promotes IFN-gamma-dependent enhancement of antitumor responses.
In previous studies, we demonstrated an immune suppressive network in non-small cell lung cancer that is due to overexpression of tumor cyclooxygenase 2 (COX-2). In this study, we assessed theExpand
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