Brian K. Meadows

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Tc-99m sestamibi is a substrate of P-glycoprotein (Pgp) that has been proposed for use as a functional imaging agent for the multidrug resistance-1 phenotype. In vitro, retention of sestamibi by cells that overexpress Pgp can be modified by the presence of Pgp antagonists. In a Phase I trial of the Pgp reversal agent PSC 833, we show that the effects of(More)
Frequency-related oscillations in coupled oscillator systems, in which one or more oscillators oscillate at different frequencies than the other oscillators, have been studied using group theoretical methods by Armbruster and Chossat [Phys. Lett. A 254, 269 (1999)] and more recently by Golubitsky and Stewart [in Geometry, Mechanics, and Dynamics, edited by(More)
We illustrate a scheme that exploits the theory of symmetry-breaking bifurcations for generating a spatio-temporal pattern in which one of two interconnected arrays, each with N Van der Pol oscillators, oscillates at N times the frequency of the other. A bifurcation analysis demonstrates that this type of frequency generation cannot be realized without the(More)
—This paper is focused on the exploitation of intrinsic nonlinear dynamics toward novel measurement systems and read-out methodologies. In particular, sensors that can be represented as nonlinear dynamical systems and are often reducible to systems described by a static nonlinearity are considered; the nonlinear behavior therefore reduces to the dynamics of(More)
—We present a novel implementation of an adaptive generalized sidelobe canceller beamformer, using a coupled nonlinear oscillator array in conjunction with an antenna array. This beamformer is applied in a narrowband wireless communication context, where there is contamination due to transmissions from similar systems. We have applied a least mean square(More)
Objective Meckel-Gruber syndrome (MKS) is a lethal ciliopathy characterised by CNS malformations, cystic kidneys, polydactyly, and liver fibrosis. Most of these can be explained by disruption of cilium-dependent signalling pathways. However, the aetiology of liver fibrosis is less well-understood. We hypothesised that alterations in cell-substrate(More)