Brian K McCandless

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UNLABELLED We evaluated whether use of a device that positions and supports the upper extremities and back during tomographic myocardial perfusion imaging reduces the incidence and severity of patient motion and patient motion artifact. METHODS We enrolled 190 patients referred for stress/redistribution myocardial perfusion imaging. All patients were(More)
We evaluated the effect of patient motion on inducing false-positive tomographic 201Tl myocardial perfusion studies. The effects of the angle of camera rotation at which movement occurs, the direction of movement and the distance of movement were studied. Movement was stimulated by shifting the raw data from normal motion-free 201Tl tomographic myocardial(More)
We studied the changes in pulmonary hemodynamics and lung wet weight induced with opsonized zymosan (OZ) in isolated guinea pig lungs perfused with Ringer-albumin solution containing neutrophils (PMNs). Addition of OZ to the PMN-perfused lungs caused pulmonary vasoconstriction and weight gain; neither OZ nor PMNs added individually to the perfusate altered(More)
We compared the effectiveness of four methods for detecting patient motion during tomographic myocardial perfusion imaging: visual inspection of a cine of the raw data, cross-correlation, diverging squares and a new method called two-dimensional fit. The methods were evaluated for their ability to detect the presence of motion, localize the camera angle at(More)
We studied polymorphonuclear neutrophil (PMN) uptake in lungs of endotoxemic rabbits using 111In-labeled PMN and isotope imaging by gamma scintigraphy. Rabbits were challenged intravenously with 100 micrograms Escherichia coli endotoxin either 4 or 24 h before an intravenous injection of 111In-labeled PMN, which was obtained from donor rabbits. The(More)
We tested the hypothesis that albumin reduces the vascular wall hydraulic conductivity by an interaction with the endothelium. The system consisted of luminal and abluminal chambers separated by a microporous filter onto which was grown a confluent monolayer of ovine pulmonary artery endothelial cells. The abluminal chamber filtrate was collected for timed(More)
We examined the role of circulating granulocytes in the pulmonary microvascular response to leukotriene B4 (LTB4) by prior depletion of circulating granulocytes using hydroxyurea. LTB4 (2 micrograms/kg injection followed by infusion of 2 micrograms/kg over 15 min) produced transient increases in pulmonary arterial pressure and pulmonary vascular resistance,(More)
OBJECTIVE The widths of most commercially-made imaging pallets limit the resolution of 99mTc DMSA SPECT imaging in neonates and young infants. We constructed a pediatric imaging pallet for 99mTc DMSA SPECT of neonates and young infants designed to allow close apposition of the camera to these patients during the entire orbit. METHODS We designed the(More)
UNLABELLED We evaluated the feasibility of cone-beam tomography (SPECT with a converging collimator) for detecting bone pathology of the distal extremities. METHODS We examined 11 patients: seven with hand or wrist pain, three with ankle pain and one with tibial pain. Cone-beam tomography was performed using a high-resolution converging collimator with a(More)