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Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab.

• Julie A Bowles, S Wang, +9 authors George J Weiner
• Blood
• 2006

Growing evidence indicates that the affinity of monoclonal antibodies (mAbs) for CD16 (FcgammaRIII) plays a central role in the ability of the mAb to mediate antitumor activity. We evaluated how CD16… (More)

Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma.

• Christopher I. van de Wetering, Mitchell C Coleman, Douglas R. Spitz, Brian J. Smith, C. Michael Knudson
• Free radical biology & medicine
• 2008

Increased reactive oxygen species (ROS) such as superoxide have been implicated as causal elements of oncogenesis. A variety of cancers have displayed changes in steady-state levels of key… (More)

Side population sorting separates subfractions of cycling and non-cycling intestinal stem cells.

• Richard J. von Furstenberg, Simon J A Buczacki, Brian J. Smith, Kristen M Seiler, Douglas J Winton, Susan J. Henning
• Stem cell research
• 2014

We report here that side population (SP) sorting allows for the simultaneous isolation of two intestinal stem cell (ISC) subsets from wild-type (WT) mice which are phenotypically different and… (More)

CD24 can be used to isolate Lgr5+ putative colonic epithelial stem cells in mice.

• Jeffrey B. King, Richard J. von Furstenberg, Brian J. Smith, Kirk K. McNaughton, Joseph Anton Galanko, Susan J. Henning
• American journal of physiology. Gastrointestinal…
• 2012

A growing body of evidence has implicated CD24, a cell-surface protein, as a marker of colorectal cancer stem cells and target for antitumor therapy, although its presence in normal colonic… (More)

Loss of LARGE2 disrupts functional glycosylation of α-dystroglycan in prostate cancer.

• Alison K. Esser, Michael R Miller, +8 authors M. David Henry
• The Journal of biological chemistry
• 2013

Dystroglycan (DG) is a cell surface receptor for extracellular matrix proteins and is involved in cell polarity, matrix organization, and mechanical stability of tissues. Previous studies documented… (More)

Intestinal stem cells remain viable after prolonged tissue storage

• Megan K. Fuller, Denver M. Faulk, +8 authors Susan J. Henning
• Cell and Tissue Research
• 2013

Intestinal stem cells (ISCs) are responsible for renewal of the epithelium both during normal homeostasis and following injury. As such, they have significant therapeutic potential. However, whether… (More)

Tissue underlying the intestinal epithelium elicits proliferation of intestinal stem cells following cytotoxic damage

• Kristen M Seiler, Erica L Schenhals, +6 authors Susan J. Henning
• Cell and Tissue Research
• 2015

The goals of this study were to document the proliferative response of intestinal stem cells (ISCs) during regeneration after damage from doxorubicin (DXR), and to characterize the signals… (More)

O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

• Joshua D. Schoenfeld, Zita A. Sibenaller, +32 authors Bryan G. Allen
• Cancer cell
• 2017

Intestinal Stem Cells in GI Physiology and Disease CD 24 can be used to isolate Lgr 5 putative colonic epithelial stem cells in mice

• Jeffrey B. King, Richard J. von Furstenberg, Brian J. Smith, Kirk K. McNaughton, Joseph Anton Galanko, Susan J. Henning
• 2012

King JB, von Furstenberg RJ, Smith BJ, McNaughton KK, Galanko JA, Henning SJ. CD24 can be used to isolate Lgr5 putative colonic epithelial stem cells in mice. Am J Physiol Gastrointest Liver Physiol… (More)

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