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  • Brian J Kirby, Ann C Collier, Evan D Kharasch, Dale Whittington, Kenneth E. Thummel, Jashvant D Unadkat
  • Medicine, Chemistry
  • Drug Metabolism and Disposition
  • 2011 (First Publication: 1 June 2011)
  • Conflicting drug-drug interaction (DDI) studies with the HIV protease inhibitors (PIs) suggest net induction or inhibition of intestinal or hepatic CYP3A. As part of a larger DDI study in healthyContinue Reading
  • Brian J Kirby, Ann C Collier, +5 authors Jashvant D Unadkat
  • Medicine, Chemistry
  • Drug Metabolism and Disposition
  • 2011 (First Publication: 1 December 2011)
  • Drug-drug interactions (DDIs) with the HIV protease inhibitors (PIs) are complex, paradoxical (e.g., ritonavir/alprazolam), and involve multiple mechanisms. As part of a larger study to betterContinue Reading
  • Md L T Vieira, Brian J Kirby, +22 authors S M Huang
  • Medicine
  • Clinical pharmacology and therapeutics
  • 2014 (First Publication: 1 February 2014)
  • Nine static models (seven basic and two mechanistic) and their respective cutoff values used for predicting cytochrome P450 3A (CYP3A) inhibition, as recommended by the US Food and DrugContinue Reading
  • Brian J Kirby, Evan D Kharasch, Kenneth T Thummel, Vishal S Narang, Christine Hoffer, Jashvant D Unadkat
  • Medicine
  • Journal of clinical pharmacology
  • 2006 (First Publication: 1 November 2006)
  • Digoxin and midazolam are routinely used as probe drugs to measure in vivo activity of P-glycoprotein (P-gp) and cytochrome P450 3A4/5 (CYP3A), respectively. We investigated whether digoxin andContinue Reading
  • Brian J Kirby, Ann C Collier, Evan D Kharasch, Dale Whittington, Kenneth E. Thummel, Jashvant D Unadkat
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • 2012 (First Publication: 1 March 2012)
  • As part of a larger clinical drug-drug interaction (DDI) study aimed at in vitro to in vivo prediction of HIV protease inhibitor metabolic and transporter-based DDIs, we measured the inductiveContinue Reading
  • Suresh Babu Naraharisetti, Brian J Kirby, Mary F. Hebert, Thomas Easterling, Jashvant D Unadkat
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical…
  • 2007 (First Publication: 1 December 2007)
  • Glyburide (glibenclamide, INN), a second generation sulfonylurea is widely used in the treatment of gestational diabetes mellitus (GDM). None of the previously reported analytical methods provideContinue Reading