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From Krebs to clinic: glutamine metabolism to cancer therapy

• Brian J Altman, Zachary E. Stine, Chi V. Dang
• Nature Reviews Cancer
• 2016

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

• Yuxing Zhao, Brian J Altman, +9 authors Jeffrey C. Rathmell
• Molecular and cellular biology
• 2007

Glucose uptake and utilization are growth factor-stimulated processes that are frequently upregulated in cancer cells and that correlate with enhanced cell survival. The mechanism of metabolic… (More)

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

• Yan Xiang, Zachary E. Stine, +21 authors Chi V. Dang
• The Journal of clinical investigation
• 2015

Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a cancer therapeutic target, but whether GLS… (More)

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

• Brian J Altman, Annie L Hsieh, +17 authors Chi V. Dang
• Cell metabolism
• 2015

The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5'-CACGTG-3'), which are identical to the binding sites of the heterodimeric CLOCK-BMAL1… (More)

MYC, Metabolism, and Cancer.

• Zachary E. Stine, Zandra E. Walton, Brian J Altman, Annie L Hsieh, Chi V. Dang
• Cancer discovery
• 2015

UNLABELLED The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC triggers selective… (More)

Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.

• Jonathan L. Coloff, Emily F Mason, +10 authors Jeffrey C. Rathmell
• The Journal of biological chemistry
• 2011

The PI3K/Akt pathway is activated in stimulated cells and in many cancers to promote glucose metabolism and prevent cell death. Although inhibition of Akt-mediated cell survival may provide a means… (More)

An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.

• Heather L. Wieman, Sarah R. Gonzales-van Horn, Sarah R. Jacobs, Brian J Altman, Sally Kornbluth, Jeffrey C. Rathmell
• The Biochemical journal
• 2009

Cell surface localization of the Glut (glucose transporter), Glut1, is a cytokine-controlled process essential to support the metabolism and survival of haemopoietic cells. Molecular mechanisms that… (More)

Metabolic stress in autophagy and cell death pathways.

• Brian J Altman, Jeffrey C. Rathmell
• Cold Spring Harbor perspectives in biology
• 2012

Growth factors and oncogenic kinases play important roles in stimulating cell growth during development and transformation. These processes have significant energetic and synthetic requirements and… (More)

MYC and metabolism on the path to cancer.

• Annie L Hsieh, Zandra E. Walton, Brian J Altman, Zachary E. Stine, Chi V. Dang
• Seminars in cell & developmental biology
• 2015

The MYC proto-oncogene is frequently deregulated in human cancers, activating genetic programs that orchestrate biological processes to promote growth and proliferation. Altered metabolism… (More)

Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.

• Brian J Altman, Jessica A. Wofford, +6 authors Jeffrey C. Rathmell
• Molecular biology of the cell
• 2009

Tissue homeostasis is controlled by the availability of growth factors, which sustain exogenous nutrient uptake and prevent apoptosis. Although autophagy can provide an alternate intracellular… (More)

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