Brian Hillen

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Following incomplete spinal cord injury (iSCI), descending drive is impaired, possibly leading to a decrease in the complexity of gait. To test the hypothesis that iSCI impairs gait coordination and decreases locomotor complexity, we collected 3D joint angle kinematics and muscle parameters of rats with a sham or an incomplete spinal cord injury. 12 adult,(More)
A traumatic spinal injury can destroy cells, irreparably damage axons, and trigger a cascade of biochemical responses that increase the extent of injury. Although damaged central nervous system axons do not regrow well naturally, the distributed nature of the nervous system and its capacity to adapt provide opportunities for recovery of function. It is(More)
Towards the development of an implantable stimulator for respiratory pacing, we have developed a computational model of the human ventilatory system to simulate breathing maneuvers. Following cervical spinal cord injury, control of breathing is lost or diminished. If the loss is severe, patients are dependent on mechanical ventilators or electrical(More)
Cervical spinal cord injury can disrupt connections between the brain respiratory network and the respiratory muscles which can lead to partial or complete loss of ventilatory control and require ventilatory assistance. Unlike current open-loop technology, a closed-loop diaphragmatic pacing system could overcome the drawbacks of manual titration as well as(More)
Spinal cord injury (SCI) can lead to changes in muscle activation patterns and atrophy of affected muscles. Moderate levels of SCI are typically associated with foot drag during the swing phase of locomotion. Foot drag is often used to assess locomotor recovery, but the causes remain unclear. We hypothesized that foot drag results from inappropriate muscle(More)
Cervical spinal cord injury (SCI) causes loss or impairment of control of respiratory muscles. Life-sustaining ventilation can be provided by mechanical ventilators (which have numerous side effects) or open-loop electrical stimulation respiratory pacing systems [1]. The use of adaptive control strategies in respiratory pacing systems can simplify initial(More)
nsed under the Creative Commons Attribution-NonCommercial ShareAlike 3.0 Unported License. To view a copy of this license, visit i ABSTRACT Spinal cord injury (SCI) disrupts the communication between supraspinal circuits and spinal circuits distal to the injury. This disruption causes changes in the motor abilities of the affected individual, but it can(More)
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