Brian G. Drew

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High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus.

Brian G. Drew, Stephen J Duffy, +15 authors Bronwyn A. Kingwell
Circulation
2009

BACKGROUND Low plasma high-density lipoprotein (HDL) is associated with elevated cardiovascular risk and aspects of the metabolic syndrome. We hypothesized that HDL modulates glucose metabolism via… (More)

Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes

Aino Soro-Paavonen, Anna M. D. Watson, +13 authors Karin Jandeleit-Dahm
Diabetes
2008

OBJECTIVE Activation of the receptor for advanced glycation end products (RAGE) in diabetic vasculature is considered to be a key mediator of atherogenesis. This study examines the effects of… (More)

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

Changhan Lee, Jennifer Zeng, +8 authors Pinchas Cohen
Cell metabolism
2015

Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open reading frame (sORF) in the mitochondrial… (More)

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

Darren C Henstridge, Clinton R Bruce, +14 authors Mark Anthony Febbraio
Diabetes
2014

Induction of heat shock protein (HSP)72 protects against obesity-induced insulin resistance, but the underlying mechanisms are unknown. Here, we show that HSP72 plays a pivotal role in increasing… (More)

Advanced Glycation End Products Are Direct Modulators of β-Cell Function

Melinda T. Coughlan, Felicia Y. T. Yap, +15 authors Josephine M Forbes
Diabetes
2011

OBJECTIVE Excess accumulation of advanced glycation end products (AGEs) contributes to aging and chronic diseases. We aimed to obtain evidence that exposure to AGEs plays a role in the development of… (More)

Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development.

Vicent Ribas, Brian G. Drew, +10 authors Andrea L. Hevener
Proceedings of the National Academy of Sciences…
2011

ERα is expressed in macrophages and other immune cells known to exert dramatic effects on glucose homeostasis. We investigated the impact of ERα expression on macrophage function to determine whether… (More)

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

Vicent Ribas, Brian G. Drew, +30 authors Andrea L. Hevener
Science Translational Medicine
2016

Impaired estrogen receptor α (ERα) action promotes obesity and metabolic dysfunction in humans and mice; however, the mechanisms underlying these phenotypes remain unknown. Considering that skeletal… (More)

Reconstituted high-density lipoprotein increases plasma high-density lipoprotein anti-inflammatory properties and cholesterol efflux capacity in patients with type 2 diabetes.

Shikharani Patel, Brian G. Drew, +9 authors Bronwyn A. Kingwell
Journal of the American College of Cardiology
2009

OBJECTIVES Our aim was to investigate the effects of reconstituted high-density lipoprotein (rHDL) infusions on plasma high-density lipoprotein (HDL) anti-inflammatory properties and ex vivo… (More)

Sex steroids modulate human aortic smooth muscle cell matrix protein deposition and matrix metalloproteinase expression.

Alaina K. Natoli, Tanya L Medley, +4 authors Bronwyn A. Kingwell
Hypertension
2005

Large artery stiffening increases cardiovascular risk and promotes isolated systolic hypertension which is more prevalent in elderly women than men. Variation in sex steroid levels between males and… (More)

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.

Claudio J. Villanueva, Laurent Vergnes, +13 authors Peter Tontonoz
Cell metabolism
2013

Transcriptional effectors of white adipocyte-selective gene expression have not been described. Here we show that TLE3 is a white-selective cofactor that acts reciprocally with the brown-selective… (More)

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