Brian D. Jensen

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Within the Mechanical Engineering department we intent to create a new full time chair, which joins the activities in the different fields of Microsystems. Are you the enthusiastic, motivating, and inspiring personality who is going to lead this chair? Miniaturization of systems and processes is a trend that is pushing the limits of current research(More)
Development of an effective cytoplasmic delivery technique has remained an elusive goal for decades despite the success of pronuclear microinjection. Cytoplasmic injections are faster and easier than pronuclear injection and do not require the pronuclei to be visible; yet previous attempts to develop cytoplasmic injection have met with limited success. In(More)
We present a non-fluidic pronuclear injection method using a silicon microchip “nanoinjector” composed of a microelectromechanical system with a solid, electrically conductive lance. Unlike microinjection which uses fluid delivery of DNA, nanoinjection electrically accumulates DNA on the lance, the DNA-coated lance is inserted into the pronucleus, and DNA(More)
The ability to inject DNA and other foreign particles into cells, both germ cells (e.g. to produce transgenic animals) and somatic cells (e.g. for gene therapy), is a powerful tool in genetic research. Nanoinjection is a method of DNA delivery that combines mechanical and electrical methods. It has proven to have higher cell viability than traditional(More)
  • John W. Sessions, Craig S. Skousen, Kevin D. Price, Brad W. Hanks, Sandra Hope, Jonathan K. Alder +1 other
  • 2016
BACKGROUND CRISPR-Cas9 genome editing and labeling has emerged as an important tool in biologic research, particularly in regards to potential transgenic and gene therapy applications. Delivery of CRISPR-Cas9 plasmids to target cells is typically done by non-viral methods (chemical, physical, and/or electrical), which are limited by low transfection(More)
This paper presents the design optimization of a RF-MEMS direct contact cantilever switch for minimum actuation voltage and opening time, and maximum power handling capability. The design variables are the length and thickness of the entire cantilever, the widths of the sections of the cantilever, and the dimple size. The actuation voltage is obtained using(More)
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