Brian D'Alessandro

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Subsurface information about skin lesions, such as the blood volume beneath the lesion, is important for the analysis of lesion severity towards early detection of skin cancer such as malignant melanoma. Depth information can be obtained from diffuse reflectance based multispectral transillumination images of the skin. An inverse volume reconstruction(More)
Detecting the early stages of melanoma can be greatly assisted by an accurate estimate of subsurface blood volume and blood oxygen saturation, indicative of angiogenesis. Visualization of this blood volume present beneath a skin lesion can be achieved through the transillumination of the skin. As the absorption of major chromophores in the skin is(More)
—Estimating the oxygen saturation of blood surrounding skin lesions is critical for the early detection of skin cancer and malignancy such as melanoma. Through multispectral transillumination of the skin, a set of images can be obtained which helps visualize areas of subsurface absorption due to chromophores such as melanin, hemoglobin, and deoxyhemoglobin.(More)
The proliferation of the lossy MP3 format as the standard for audio transferred over the internet is of great concern to audiophiles, those who deeply care about good audio quality. Typically, the bit rate of an MP3 file is used as a relative measure of audio quality, however, this check fails if the audio has been transcoded from a lower bit rate to a(More)
Multispectral transillumination imaging is a promising modality for noninvasive imaging of living tissue. Multispectral Nevoscope imaging is directed toward the imaging of skin lesions for the detection and characterization of skin cancers through the volumetric analysis of selected chromophores, such as melanin, oxy-, and deoxyhemoglobin. In this letter,(More)
To better understand fundamental issues, perception studies of the fusion display would best be performed with a panel of lesions of variable location, size, intensity, and background. There are compelling reasons to use synthetic images that contain artificial lesions for perception research. A consideration of how to obtain this panel of lesions is the(More)
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