Brian D Acacio

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Before effective treatment for reproductive failure can be instituted, the cause of the failure must be determined. A search of PubMed was made to identify the published data regarding diagnosis and treatment of reproductive failure. Results were compared with the frequency of antiphospholipid antibodies (APA) in 2995 women with histories of unexplained(More)
BACKGROUND In vitro investigations have revealed the ability of intralipids to suppress natural killer (NK) cytotoxicity. Evidence from both animal and human studies suggests that intralipid administered intravenously may enhance implantation and maintenance of pregnancy when the patient has an abnormal NK cell level or function. PROBLEM The aim of this(More)
OBJECTIVE To detect hCG in spent embryo culture media at day 2 after intracytoplasmic sperm injection and to assess the relationship of hCG to embryo development. DESIGN Experimental study. SETTING Fertility center and clinical diagnostic laboratory. SAMPLE(S) A total of 102 spent culture media from day 2 human embryos and corresponding unexposed(More)
OBJECTIVE To determine: [1] what percentage of men in an infertile relationship will have a semen abnormality, [2] the average value for each semen parameter in this group of men, [3] the distribution of abnormal semen parameters in this group, and [4] if our data support the hypothesis that sperm concentration is declining. DESIGN Retrospective cohort(More)
OBJECTIVE To evaluate what hormonal or biochemical parameters are most highly associated with the finding of polycystic-appearing ovaries as compared with normal-appearing ovaries in women with polycystic ovary syndrome (PCOS). DESIGN Prospective randomized study. SETTING Academic medical center. PATIENTS Ten women with PCOS-five with normal-appearing(More)
BACKGROUND We have previously reported the retrospective observation that when at least one embryo, transferred on day 3, expressed sHLA-G above the geometric mean (sHLA-G+) 46 h post-ICSI, there was a marked improvement in both pregnancy (PR) and implantation (IR) rates. METHODS The media surrounding individual embryos derived from ICSI performed on(More)
OBJECTIVE To determine the effects of dehydroepiandrosterone (DHEA) supplementation on the pharmacokinetics of DHEA and its metabolites and the reproductive axis of healthy young men. DESIGN A prospective, randomized, double-blind, placebo-controlled pharmacokinetic study. SETTING General Clinical Research Center and laboratories at the Keck School of(More)
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