Brian Collette

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The chemokine CXCL12 and its receptor CXCR4 are expressed widely in human cancers, including ovarian cancer, in which they are associated with disease progression at the levels of tumor cell proliferation, invasion, and angiogenesis. Here, we used an immunocompetent mouse model of intraperitoneal papillary epithelial ovarian cancer to show that modulation(More)
Vaccine and Immunotherapy Center, Infectious Diseases Medicine, Massachusetts General Hospital, Charlestown, MA Department of Experimental Medicine and IST Cancer Research, Genoa University, Italy Molecular Pathology, Massachusetts General Hospital, Boston, MA Department of Zoology, Clare College, Cambridge, UK Dept of Haematology, Padua University(More)
Epidemiologic and experimental evidence for a relation between high body weight and breast cancer is reviewed. A prospective study in the framework of a population-based breast cancer screening project for women over age 50 with determination of estrogen-receptor-status of cancers has provided evidence that promotion of ER-positive cases is favored by(More)
Safe and effective immunologic adjuvants are often essential for vaccines. However, the choice of adjuvant for licensed vaccines is limited, especially for those that are administered intradermally. We show that non-tissue damaging, near-infrared (NIR) laser light given in short exposures to small areas of skin, without the use of additional chemical or(More)
In medical usage, relative operating characteristics (ROC) refer to the symptoms, signs, and laboratory values used for making a diagnosis. Diagnosis analysis by ROC measures diagnosis performance independently of the diagnostic criteria used, thus revealing the arbitrary character of diagnosis. In order to carry out ROC analysis, the diagnosis has to be(More)
Quantitative Röntgen microdensitometry (QMD) can be used to provide a precise quantification of mean specific bone mass (rho) from standardized radiographs. The method is simple, non-invasive, low in cost and suitable for frequent repetition. Bone mineral mass at the mid-length (largely cortical bone) of the middle phalanx of digital II of the left and(More)
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