Brian Clarke

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Docking is a computational technique that samples conformations of small molecules in protein binding sites; scoring functions are used to assess which of these conformations best complements the protein binding site. An evaluation of 10 docking programs and 37 scoring functions was conducted against eight proteins of seven protein types for three tasks:(More)
a r t i c l e i n f o Keywords: bedrock fractures threshold slopes landslides landscape evolution erosion Bedrock fracturing and rock strength are widely believed to influence landscape morphology and erosional resistance. Yet, understanding of the quantitative relationship between rock-mass strength and landscape evolution remains limited. Here we present(More)
[1] The role of bedrock fractures and rock mass strength is often considered a primary influence on the efficiency of surface processes and the morphology of landscapes. Quantifying bedrock characteristics at hillslope scales, however, has proven difficult. Here, we present a new field‐based method for quantifying the depth and apparent density of bedrock(More)
In July 2007, a study by the Centre for Environmental Health Engineering, at the University of Surrey, assessed a modified method of jerry can cleaning in an internally displaced persons (IDP) camp in Kitgum, N. Uganda. The poor condition of drinking water vessels used in the camp was confirmed as a potential source for microbiological contamination both(More)
BACKGROUND Sudden death (SD) and non-sudden cardiac death are responsible for the majority of deaths in patients with heart failure. We sought to identify the influence of comorbid illness (Charlson Comorbidity Index [CCI]) on competing modes of death in heart failure. METHODS A retrospective analysis of 824 patients followed in a tertiary care heart(More)
BACKGROUND Transplantation of sensitized recipients has been associated with increased risk of post-transplant complications. In 2010, the Canadian Cardiac Transplant Network (CCTN) created a unique status listing for highly sensitized heart transplant candidates. Status 4S listing requires calculated panel-reactive antibody (cPRA) level >80% as the sole(More)
responsible for cefoxitin resistance in Escherichia coli. We examined the relative importance of each. We studied 18 strains of clinical isolates with reduced cefoxitin susceptibility and 10 initially-susceptible strains passaged through cefoxitin-gradient plates. Of 18 wild-resistant strains, 9 had identical promoter mutations (including creation of a(More)
There is currently limited public information available concerning methods for the selection of appropriate water treatment technologies for application in acute phase emergency water and sanitation responses. Considering the number of available emergency water treatment and supply options, it is speculated that a framework methodology offering guidance in(More)
The hydrologic connectivity between hillslopes and streams impacts the geomorphological evolution of catchments. Here, we propose a conceptual model for hydrogeomorphological evolution of the Susquehanna Shale Hills Critical Zone Observatory (SSHCZO), a first-order catchment developed on shale in central Pennsylvania, U.S.A. At SSHCZO, the majority of(More)
PURPOSE OF REVIEW Death and hospitalization for acutely decompensated heart failure are predominantly due to volume overload, have increased in the past 10 years, carry poor outcomes, and are costly to the healthcare system. Clinical monitoring with daily weight and symptoms is relatively insensitive for early detection of volume overload. This lack of(More)