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OBJECTIVES Epithelial gaps resulting from intestinal cell extrusions can be visualized with confocal laser endomicroscopy (CLE) during colonoscopy and increased in normal-appearing terminal ileum of inflammatory bowel disease (IBD) patients. Cell-shedding events on CLE were found to be predictive of disease relapse. The aim of this study was to assess the(More)
Placebo treatments and healing rituals have been used to treat pain throughout history. The present within-subject crossover study examines the variability in individual responses to placebo treatment with verbal suggestion and visual cue conditioning by investigating whether responses to different types of placebo treatment, as well as conditioning(More)
Expectations shape the way we experience the world. In this study, we used fMRI to investigate how positive and negative expectation can change pain experiences in the same cohort of subjects. We first manipulated subjects' treatment expectation of the effectiveness of three inert creams, with one cream labeled "Lidocaine" (positive expectancy), one labeled(More)
BACKGROUND Although clear evidence shows that chronic kidney disease is a predictor of cardiovascular events, death, and accelerated coronary artery disease (CAD) progression, it remains unknown whether CAD is a predictor of progression of chronic kidney disease to end-stage renal disease. We sought to assess whether CAD adds prognostic information to(More)
BACKGROUND Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital-based studies suggest that African Americans may have reduced circulating natriuretic peptides, as compared to(More)
AIMS In this analysis, we utilized data from PARADIGM-HF to test the hypothesis that participants who exhibited any dose reduction during the trial would have similar benefits from lower doses of sacubitril/valsartan relative to lower doses of enalapril. METHODS AND RESULTS In a post-hoc analysis from PARADIGM-HF, we characterized patients by whether they(More)
Meta-analysis is a valuable tool for combining information from independent studies. However, most common meta-analysis techniques rely on distributional assumptions that are difficult, if not impossible, to verify. For instance, in the commonly used fixed-effects and random-effects models, we take for granted that the underlying study-level parameters are(More)
  • Citation Kong, Rosa Jian, Amanda Spaeth, Irving Cook, Brian Kirsch, Mark Claggett +12 others
  • 2013
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Placebo treatments and healing rituals have been used to treat pain throughout history. The present within-subject crossover study examines the variability in individual responses to placebo treatment with verbal suggestion(More)
  • Citation Kong, Rosa Jian, Amanda Spaeth, Irving Cook, Brian Kirsch, Mark Claggett +13 others
  • 2013
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Placebo treatments and healing rituals have been used to treat pain throughout history. The present within-subject crossover study examines the variability in individual responses to placebo treatment with verbal suggestion and(More)
Meta-analysis is a valuable tool for combining information from independent studies. However, most common meta-analysis techniques rely on distributional assumptions that are difficult, if not impossible, to verify. For instance, in the commonly used fixed-effects and random-effects models, we take for granted that the underlying study parameters are either(More)
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