Brian C Beckett

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Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic enzymes that share a fold and catalytic mechanism yet possess strict specificity for their substrates. In the Apicomplexa, convergent evolution of an unusual LDH from MDH produced a difference in specificity exceeding 12 orders of magnitude. The mechanisms responsible for this(More)
The K2 Summit camera was initially the only commercially available direct electron detection camera that was optimized for high-speed counting of primary electrons and was also the only one that implemented centroiding so that the resolution of the camera can be extended beyond the Nyquist limit set by the physical pixel size. In this study, we used(More)
A variety of human diseases including Malaria are caused by unicellular eukaryotes of the genus Apicomplexa, which have evolved highly specific lactate dehydrogenase (LDH) from malate dehydrogenase (MDH). The importance of LDH to the parasitic life cycles of modern Apicomplexans makes it a major drug target. The presence of a promiscuous intermediate in the(More)
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