Brian C Andrews-Shigaki

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PURPOSE To introduce and evaluate a method of prospective motion correction for localized proton magnetic resonance spectroscopy (1H-MRS) using a single-camera optical tracking system. MATERIALS AND METHODS Five healthy participants were scanned at 3T using a point-resolved spectroscopic sequence (PRESS) with a motion-tracking module and phase navigator.(More)
PURPOSE The goal of this study was to compare the accuracy of two real-time motion tracking systems in the MR environment: MR-based prospective motion correction (PROMO) and optical moiré phase tracking (MPT). METHODS Five subjects performed eight predefined head rotations of 8° ± 3° while being simultaneously tracked with PROMO and MPT. Structural images(More)
N-acetylaspartate (NAA) is recognized as a noninvasive diagnostic neuronal marker for a host of neuropsychiatric disorders using magnetic resonance spectroscopy (MRS). Numerous correlative clinical studies have found significant decreases in NAA levels in specific neuronal systems in an array of neuropsychiatric and substance-abuse disorders. We have(More)
We investigated the association of systemic and local tissue stress responses with heat-tolerant (TOL) levels in mice. Thirty-eight mice were assigned into control and three heat exposure groups-TOL, moderately tolerant, and intolerant (INT), based on their overall thermal responses. Real-time core temperature, blood pressure, and heart rate (HR) were(More)
BACKGROUND Methamphetamine can be neurotoxic to the adult brain; however, many individuals first use methamphetamine during adolescence, and the drug's impact on this period of brain development is unknown. Therefore, we evaluated young methamphetamine users for possible abnormalities in brain metabolite concentrations. METHODS Anterior cingulate cortex(More)
The family of heat shock proteins works at the cellular level to protect cells against many chronically and acutely induced stressful conditions. The induction of certain family members, such as HSP70 and HSP90 via a heat shock factor 1 activated pathway, may have broad therapeutic benefits in the treatment of various types of tissue trauma and metabolic(More)
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