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The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein(More)
Alzheimer's disease is characterized by amyloid-beta peptide (Abeta)-loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor (APP) and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 (SP1),(More)
Jinfang Wu,1 Md. Riyaz Basha,1 Brian Brock,1 David P. Cox,2 Fernando Cardozo-Pelaez,2 Christopher A. McPherson,3 Jean Harry,3 Deborah C. Rice,4 Bryan Maloney,5 Demao Chen,5 Debomoy K. Lahiri,5 and Nasser H. Zawia1 1Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, 2Department of Biomedical and(More)
Introduction Contemporary anthropologies frequently locate disability, and persons with disabilities, on the margins of both anthropological discourse and society, deeming them to be ‘special cases’ and thus problematic. Brian Brock begins this Reader with the following claim: ‘Any approach to the topic of disability inexorably leads to the “problem of the(More)
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