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Contact inhibition of locomotion determines cell–cell and cell–substrate forces in tissues
A computational model is used to study the forces generated by cells in tissues and the resultant cell motion, and develops a particle-based simulation model for adhesive cell clusters and monolayers to understand how cellular forces are generated and how they can influence the tissue state.
Diffusion of complex objects embedded in free and supported lipid bilayer membranes: role of shape anisotropy and leaflet structure
We present a versatile numerical scheme to predict diffusion coefficients for arbitrarily shaped objects embedded in lipid bilayer membranes. Diffusion coefficients for micron-scale diamond-shaped
Polarity mechanisms such as contact inhibition of locomotion regulate persistent rotational motion of mammalian cells on micropatterns
It is argued that the existence or absence of rotation under confinement may lead to insight into the cell’s methods for coordinating collective cell motility, as well as the effect of various cell polarity mechanisms on rotational motion.
Periodic migration in a physical model of cells on micropatterns.
It is shown that periodic motion emerges naturally from the coupling of cell polarization to cell shape by reducing the model to a simplified one-dimensional form that can be understood analytically.
Dynamic scaling in phase separation kinetics for quasi-two-dimensional membranes.
It is argued that the diversity of scaling exponents measured in experiment and prior simulations can in part be attributed to certain measurements lying outside the asymptotic long-length-scale regime, and a framework is provided to help understand these results.
Modeling Contact Inhibition of Locomotion of Colliding Cells Migrating on Micropatterned Substrates
This work identifies the parameters that control transitions between the different cases of cell-cell adhesion, propulsion strength, and the rates of CIL, and suggests hypotheses for why different cell types have different collision behavior and the effect of interventions that modulate collision outcomes.
Physical models of collective cell motility: from cell to tissue.
A range of techniques are discussed, ranging from models that represent cells as simple self-propelled particles to phase field models that can represent a cell's shape and dynamics in great detail, which extensively review the ways in which cells within a tissue choose their direction.
Lipid and Peptide Diffusion in Bilayers: The Saffman-Delbrück Model and Periodic Boundary Conditions.
The periodic PSD model is tested using the coarse-grained Martini and all-atom CHARMM36 (C36) force fields and a Bayesian method for extrapolating diffusion constants of lipids and proteins in membranes obtained from simulation to infinite system size is provided.
Strong influence of periodic boundary conditions on lateral diffusion in lipid bilayer membranes.
I simulations of LacY membrane protein diffusion and LacY dimer diffusion in DPPC membranes and lipid diffusion in pure DPPC bilayers support the underlying hydrodynamic model.
Dynamic simulations of multicomponent lipid membranes over long length and time scales.
We present a stochastic phase-field model for multicomponent lipid bilayers that explicitly accounts for the quasi-two-dimensional hydrodynamic environment unique to a thin fluid membrane immersed in