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A novel test procedure for antidepressants was designed in which a mouse is suspended by the tail from a lever, the movements of the animal being recorded. The total duration of the test (6 min) can be divided into periods of agitation and immobility. Several psychotropic drugs were studied: amphetamine, amitriptyline, atropine, desipramine, mianserin,(More)
1. Mice when suspended by the tail will alternate between active attempts to escape and immobility. Immobility like that measured in the behavioral despair test is reduced by a wide variety of antidepressant agents. 2. The present paper describes a computerized version of this test (ITEMATIC-TST) which in addition to recording immobility measures the power(More)
The model proposed here assumes that depressive disorders could reflect an extreme state of a current behavioral strategy. According to this model, a subject facing a problem of survival without apparent solution may choose between two behavioral patterns: searching for a solution or waiting for that solution to occur. This choice can be made after one or(More)
In the tail suspension test (TST), the rat is suspended by the tail for 6 min during which the animal shows periods of agitation and immobility. The duration of the immobility is measured. Desipramine decreased the duration of immobility. The main advantages of this procedure are: the use of a simple, objective test situation; the concordance of the results(More)
OBJECTIVE To evaluate the perceptive and linguistic results in 2 predefined genetic population of children with implants. STUDY DESIGN Retrospective cohort study. SETTING Otolaryngology department of a tertiary referral hospital. PATIENTS Among 336 children with prelingual deafness who underwent implantation in our department between 1997 and 2007, 85(More)
Eleven benzodiazepines were evaluated in the staircase test in mice. The behavioural parameters measured were the number of steps climbed and the number of rears during a 3-min test. Climbing and to a lesser extent rears were enhanced at low doses, whereas both parameters, particularly rearing, were reduced at higher doses. The differential effects of the(More)
The greeting behavior of rhesus monkeys (Macaca mulatta) was evaluated in a pharmacological test. It was observed in pairs of juvenile subjects reunited after a separation of two days. The observational measures were the duration of greeting behavior (social grooming, social play, and huddling) and the frequency of presentations, mounts and solicitations.(More)
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