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Several reports in the literature suggested that environmental influences which are reflected in the social housing conditions of the rat may play a role in the expression of individual differences in drug self-administration. The present experiments were performed in order to further examine the effects of early housing manipulations, as reflected by(More)
The scaling of social entrepreneurial impact is an important issue in the field of social entrepreneurship. While researchers have focused relatively little theoretical and empirical attention on scaling, a recently proposed set of drivers of scaling – incorporated into what has been labeled the SCALERS model – may provide guidance for new theoretical and(More)
The effects of THIP (GABAA agonist) and picrotoxin (GABA antagonist) on the maintenance of voluntary ethanol ingestion were examined. Thirty-three male Long-Evans rats were initially exposed to a screening procedure in which increasing concentrations of ethanol (from 2% to 9%) were presented in a free choice with water, on an alternate day schedule.(More)
The present study was designed to explore the interactive effects of nicotine and ethanol in the pretreatment and preexposure conditioned taste aversion (CTA) paradigm. The first experiment examined the effects of ethanol pretreatment on a nicotine induced CTA. The second experiment examined the effects of nicotine pretreatment on an ethanol CTA. The(More)
The effects of GABAA agonist THIP on the acquisition of voluntary ethanol intake and the pattern of food and water consumption were examined through the use of a computer-controlled data acquisition system. Twenty male Long-Evans rats were randomly assigned to two groups, one of which received THIP (16 mg/kg, IP) and the other an equal volume of saline.(More)
The present study examined the behavioral processes mediating the influence of the GABA(B) agonist baclofen on the maintenance of voluntary ethanol intake. Long-Evans rats were randomly assigned to two groups, one receiving baclofen (10 mg/kg, IP) and the other an equal volume of saline. Subjects were presented with a free choice of ethanol (10% v/v) and(More)
Treatment with the GABAA agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) or the GABAB agonist baclofen was shown to enhance the acquisition of voluntary ethanol consumption in laboratory rats. THIP administration resulted in an increased intake of absolute ethanol without an increase in total fluid intake. In contrast, baclofen administration,(More)
Within the context of the role of serotonin (5-HT) in motivated behavior, the authors examine the effects of 5-HT uptake inhibitors on the regulation of motivated consummatory behavior. Emphasis in this field has for the most part focused on the consistent observation that treatment with these agents attenuates voluntary ethanol drinking behavior in both(More)
The stress-activated mitogen-activated protein kinase (MAPK) p38 has been linked to the production of inflammatory cytokines/mediators/inflammation and death/apoptosis following cell stress. In these studies, a second-generation p38 MAPK inhibitor, SB 239063 (IC(50) = 44 nM), was found to exhibit improved kinase selectivity and increased cellular (3-fold)(More)
Observations in humans suggest that the initial use of tobacco occurs in close temporal proximity to experimentation with alcohol. There have been relatively few research reports, however, examining possible interactions between these two agents. The present experiments examined the effect of nicotine exposure on the acquisition of ethanol drinking behavior(More)