Brett P Blake

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Active and passive Abeta immunotherapy provide behavioral benefits in AD transgenic mice, but they can also induce adverse immune over-activation and neuropathological effects. Here, we show that a restricted Abeta-specific immune re-activation can provide cognitive and pathological benefits to APPsw + PS1 transgenic mice for at least 2 1/2 months. A single(More)
Distinction between melanoma in situ (MIS) and solar lentigo (SL) on chronically sun-damaged skin (CSDS) by hematoxylin and eosin (H&E) criteria alone can be difficult and in frozen section (FS) material, may be virtually impossible without immunohistochemistry (IHC). In this study, we used microphthalmia-associated transcription factor (MITF) IHC-directed(More)
BACKGROUND Transposition flaps are frequently used to repair defects of the head and neck after tumor extirpation with Mohs micrographic surgery. OBJECTIVE To review the basic principles underlying single-stage transposition flaps and also their utility relative to location on the head and neck. MATERIALS AND METHODS A review of the literature on(More)
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