Brett Macdonald

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Neurofibrillary tangles (NFT), neuritic plaques and amyloid load were quantified in sections of the hippocampus at the level of the lateral geniculate body in 41 consecutive cases fulfilling pathological criteria for diagnosis of Alzheimer's disease (AD) and coming to autopsy after longitudinal study during life. A strong correlation was found between NFT(More)
A 53-year-old woman with major depression was studied throughout 7 trials of therapeutic sleep deprivation (SD). Under conditions where the patients was either medication-free or receiving antidepressant therapy, improvement with SD was followed by full relapse on returning to sleep. Four SD sessions conducted while the patient was receiving thyroxine each(More)
Facial asymmetries during emotional arousal were studied under conditions designed to produce spontaneous responses. Subjects who performed a difficult verbal task reported unpleasant emotions, tested high on state anxiety and showed greater changes in left than right-sided composite photographs compared to the relaxed state. Subjects who performed an easy(More)
We aimed to clarify the event-related potentials (ERPs) involved in elicitation and habituation of the orienting reflex (OR), seeking parallels with two autonomic measures reflecting different stages in OR-related processing. Participants were presented with 8 unexpected innocuous novel tones to one ear at long variable inter-stimulus intervals, and(More)
This study examined autonomic measures and event-related potentials (ERPs) associated with elicitation and habituation of the basic Orienting Reflex (OR). Subjects received 16 innocuous tones with intensity alternating between 60 and 80 dB, at long inter-stimulus intervals. There was no stimulus-related task, so we could examine the effects of stimulus(More)
The phasic orienting reflex (OR) was investigated using single-trial data collected concurrently from 4 autonomic measures and event-related potentials (ERPs). In an auditory dishabituation paradigm, twelve indifferent tones of two intensities (60 or 80 dB, intensity change on trial 11, counterbalanced between subjects) were presented at very long(More)
Single-trial data from autonomic and ERP measures were used to capture the rapidly decreasing initial responses characteristic of the orienting reflex (OR) to repeated stimuli. Stimulus-response patterns were compared to determine central analogues of autonomic indices of processes leading to the OR, and the OR itself. Participants were presented with 12(More)
We aimed to clarify the event-related potentials (ERPs) associated with elicitation and habituation of the basic Orienting Reflex (OR). Participants were presented with 16 innocuous tones, alternating in intensity, at long variable inter-stimulus intervals, with no task. This allowed us to examine stimulus novelty and intensity effects in the absence of(More)
The effect of a single oral dose of caffeine was examined in a randomised double-blind placebo-controlled repeated-measures cross-over study. Eighteen children with AD/HD, aged between 8 and 13 years, were individually age- and gender-matched with a control group. All children participated in two sessions, one week apart. Skin conductance level (SCL) from a(More)
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