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Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary restriction consistently extends lifespan and delays age-related diseases in evolutionarily diverse organisms. Similar conditions of nutrient limitation and genetic or pharmacological perturbations of nutrient or energy metabolism also have longevity benefits. Recently,(More)
Small-molecule target identification is a vital and daunting task for the chemical biology community as well as for researchers interested in applying the power of chemical genetics to impact biology and medicine. To overcome this "target ID" bottleneck, new technologies are being developed that analyze protein-drug interactions, such as drug affinity(More)
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control 1. With prevalent hyper-activation of the mTOR pathway in human cancers 2 , novel strategies to enhance Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions(More)
SMER3 prevents the assembly of SCF Met30 or induces SCF complex dissociation Presently we are unable to distinguish between these two possible modes of action by SMER3. Attempts to detect SMER3-dependent release of Met30 from the SCF complex in vitro were unsuccessful. Furthermore, complex assembly cannot be studied in vitro since Met30 expressed without(More)
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