Brett J. Manley

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BACKGROUND High flow nasal cannulae (HFNC) are small, thin, tapered binasal tubes that deliver oxygen or blended oxygen/air at gas flows of more than 1 L/min. HFNC are increasingly being used as a form of non-invasive respiratory support for preterm infants. OBJECTIVES To compare the safety and efficacy of HFNC with other forms of non-invasive respiratory(More)
From the Newborn Research Centre, Royal Women’s Hospital (B.J.M., L.S.O., L.W.D., P.G.D.), the Departments of Obstetrics and Gynaecology (B.J.M., L.S.O., L.W.D., P.G.D.) and Paediatrics (L.W.D., S.M.D.), University of Melbourne, and the Critical Care and Neurosciences Theme (B.J.M., L.S.O., L.W.D., P.G.D.) and Clinical Epidemiology and Biostatistics Unit(More)
BACKGROUND Docosahexaenoic acid (DHA) has been associated with downregulation of inflammatory responses. OBJECTIVE To report the effect of DHA supplementation on long-term atopic and respiratory outcomes in preterm infants. METHODS This study is a multicenter, randomized controlled trial comparing the outcomes for preterm infants <33 weeks' gestation(More)
BACKGROUND Treatment with nasal high-flow therapy has efficacy similar to that of nasal continuous positive airway pressure (CPAP) when used as postextubation support in neonates. The efficacy of high-flow therapy as the primary means of respiratory support for preterm infants with respiratory distress has not been proved. METHODS In this international,(More)
BACKGROUND Randomised trials suggest that high-flow (HF) therapy is comparable with continuous positive airway pressure (CPAP) for postextubation respiratory support in neonates, and HF has been widely adopted in neonatal intensive care. METHODS We conducted a population-based study of very preterm infants born <32 weeks' gestation within the Australian(More)
BACKGROUND Noise exposure in the neonatal intensive care unit is believed to be a risk factor for hearing loss in preterm neonates. Continuous positive airway pressure (CPAP) devices exceed recommended noise levels. High flow nasal cannulae (HFNC) are an increasingly popular alternative to CPAP for treating preterm infants, but there are no in vivo studies(More)
Effective resuscitation of the newborn infant has the potential to save many lives around the world and reduce disabilities in children who survive peripartum asphyxia. In this Series paper, we highlight some of the important advances in the understanding of how best to resuscitate newborn infants, which includes monitoring techniques to guide resuscitative(More)
BACKGROUND High-flow nasal cannulae (HFNC) are gaining in popularity as a form of non-invasive respiratory support for preterm infants in neonatal intensive care units around the world. They are proposed as an alternative to nasal continuous positive airway pressure (NCPAP) in a variety of clinical situations, including post-extubation support, primary(More)
AIM Non-tertiary centres (NTCs) in Australia and New Zealand are increasingly providing non-invasive respiratory support, including high-flow nasal cannulae (HFNC) and nasal continuous positive airway pressure (nCPAP), to newborn infants. We aimed to determine the proportion of NTCs in these countries treating newborn infants with HFNC and nCPAP, and how(More)
BACKGROUND Some neonatologists state that at the delivery of extremely premature infants they rely on "how the baby looks" when deciding whether to initiate resuscitation. Previous studies have reported poor correlation between early clinical signs and prognosis. OBJECTIVE To determine if neonatologists can accurately predict survival to discharge of(More)