Brett D. Hambly

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Elite endurance athletes and the ACE I allele – the role of genes in athletic performance

George Gayagay, Bing Yu, +4 authors Ronald J. A. Trent
Human Genetics
1998

Genetic markers that might contribute to the making of an elite athlete have not been identified. Potential candidate genes might be found in the renin-angiotensin pathway, which plays a key role in… (More)

Quantitative N-linked glycoproteomics of myocardial ischemia and reperfusion injury reveals early remodeling in the extracellular environment.

Benjamin L. Parker, Giuseppe Palmisano, +9 authors Stuart James Cordwell
Molecular & cellular proteomics : MCP
2011

Extracellular and cell surface proteins are generally modified with N-linked glycans and glycopeptide enrichment is an attractive tool to analyze these proteins. The role of N-linked glycoproteins in… (More)

Molecular pathology of familial hypertrophic cardiomyopathy caused by mutations in the cardiac myosin binding protein C gene.

Bing Yu, Julie A. French, +8 authors Ronald J. A. Trent
Journal of medical genetics
1998

DNA studies in familial hypertrophic cardiomyopathy (FHC) have shown that it is caused by mutations in genes coding for proteins which make up the muscle sarcomere. The majority of mutations in the… (More)

Orientation of spin-labeled light chain-2 exchanged onto myosin cross-bridges in glycerinated muscle fibers.

Brett D. Hambly, Kathleen E Franks, Roger Cooke
Biophysical journal
1991

Electron paramagnetic resonance (EPR) spectroscopy has been used to study the angular distribution of a spin label attached to rabbit skeletal muscle myosin light chain 2. A cysteine reactive spin… (More)

Metformin inhibits the development and metastasis of ovarian cancer.

Buchu Wu, Shu Li, +7 authors Wen Di
Oncology reports
2012

The aim of this study was to investigate the role of metformin in the regulation of development and metastasis of ovarian carcinoma cell lines in vitro and ovarian cancer in a… (More)

Myosin binding protein-C: enigmatic regulator of cardiac contraction.

C. Elizabeth Oakley, Jean E Chamoun, Louise Jennifer Brown, Brett D. Hambly
The international journal of biochemistry & cell…
2007

Myosin binding protein C (MyBPC) is a sarcomeric protein whose role in sarcomere structure and regulation of contraction is currently under investigation. It is a member of the immunoglobulin… (More)

Granulocyte-macrophage colony-stimulating factor enhances wound healing in diabetes via upregulation of proinflammatory cytokines.

Yi-bin Fang, Jiang Shen, Melissa Min-Szu Yao, Kenneth W. Beagley, Brett D. Hambly, Shideng Bao
The British journal of dermatology
2010

BACKGROUND Chronic ulceration, especially in diabetes, remains a substantial clinical problem. Exogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) is efficacious in the treatment of… (More)

Modifications of myosin-regulatory light chain correlate with function of stunned myocardium.

Melanie Yvonne White, Stuart James Cordwell, Hugh C. K. McCarron, Adrian S Tchen, Brett D. Hambly, Richmond W. Jeremy
Journal of molecular and cellular cardiology
2003

The precise molecular basis for myocardial stunning remains unresolved, but protein damage within the myofibril is a likely mechanism. We used two-dimensional gel electrophoresis (2-DE) and mass… (More)

Increased total heart rate variability and enhanced cardiac vagal autonomic activity in healthy humans with sinus bradycardia.

Craig McLachlan, Ryan Ocsan, +4 authors Herbert F. Jelinek
Proceedings
2010

Sinus bradycardia can be defined as a sinus rhythm with a resting heart rate of 60 beats per minute or less. While it is assumed that increased autonomic parasympathetic activity is associated with… (More)

Oceanimonas smirnovii sp. nov., a novel organism isolated from the Black Sea.

Elena P Ivanova, Olga M Onyshchenko, +6 authors Elena A Kiprianova
Systematic and applied microbiology
2005

A slightly creamy, melanogenic, gram-negative, aerobic bacterium was isolated from seawater sample collected in the Karadag Natural Reserve of the Eastern Crimea, the Black Sea. The novel organism… (More)

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