Brett Clark

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Katanin is an evolutionarily conserved microtubule-severing complex implicated in multiple aspects of microtubule dynamics. Katanin consists of a p60 severing enzyme and a p80 regulatory subunit. The p80 subunit is thought to regulate complex targeting and severing activity, but its precise role remains elusive. In lower-order species, the katanin complex(More)
A significant percentage of young men are infertile and, for the majority, the underlying cause remains unknown. Male infertility is, however, frequently associated with defective sperm motility, wherein the sperm tail is a modified flagella/cilia. Conversely, a greater understanding of essential mechanisms involved in tail formation may offer contraceptive(More)
Solid assembly meshing has all of the same " dirty geometry " induced issues as single part meshing but also has the difficulty associated with generating a confor-mal mesh between solids where solid-solid interfaces are not obvious. Mesh generators usually don't have CAD assembly constraint information to identify interfacing solids and must therefore rely(More)
Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity. Disturbance of splicing regulation is associated with many human diseases; however, key splicing factors that control tissue-specific(More)
This study examines the regional and temporal differences in the statistical relationship between national-level carbon dioxide emissions and national-level population size. The authors analyze panel data from 1960 to 2005 for a diverse sample of nations, and employ descriptive statistics and rigorous panel regression modeling techniques. Initial(More)
The Immersive Topology Environment for Meshing (ITEM) is a wizard-like environment, built on top of the CUBIT Geometry and Meshing Toolkit. ITEM is focused on three main objectives: 1) guiding the user through the simulation model preparation workflow; 2) providing the user with intelligent options based upon the current state of the model; and 3) where(More)
There are several compelling reasons to expect that gender equality may serve to foster state environ-mentalism. However, most previous research on environmental politics has neglected gender. To help further our understanding of the connection between gender and environmental politics, the authors empirically assess the association between the(More)
The integrity of male germ cell genome is critical for the correct progression of spermatogenesis, successful fertilization, and proper development of the offspring. Several DNA repair pathways exist in male germ cells. However, unlike somatic cells, key components of such pathways remain largely unidentified. Gametogenetin (GGN) is a testis-enriched(More)
Preparing Computer Aided Design models for successful mesh generation continues to be a crucial part of the design to analysis process. A common problem in CAD models is features that are very small compared to the desired mesh size. Small features exist for a variety of reasons and can require an excessive amount of elements or inhibit mesh generation all(More)
The vague, yet undoubtedly desirable, notion of sustainability has been discussed and debated by many natural and social scientists. We argue that mainstream conceptions of sustainability, and the related concept of sustainable development, are mired in a " pre-analytic vision " that naturalizes capitalist social relations, closes off important questions(More)