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- Stanley Nattel, Brett Burstein, Dobromir Dobrev
- Circulation. Arrhythmia and electrophysiology
- 2008
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It can occur at any age but is very rare in children and becomes extremely common in the elderly, with a prevalence… (More)
- Brett Burstein, Stanley Nattel
- Journal of the American College of Cardiology
- 2008
Atrial fibrillation (AF) is the most common arrhythmia in the clinical setting, and traditional pharmacological approaches have proved to have important weaknesses. Structural remodeling has been… (More)
- Brett Burstein, Eric Libby, Angelino Calderone, Stanley Nattel
- Circulation
- 2008
BACKGROUND
In various heart disease paradigms, atria show stronger fibrotic responses than ventricles. The possibility that atrial and ventricular fibroblasts respond differentially to pathological… (More)
- Xiao Yan Qi, Yung-Hsin Yeh, +7 authors Stanley Nattel
- Circulation research
- 2008
Atrial tachycardia (AT) downregulates L-type Ca(2+) current (I(CaL)) and causes atrial fibrillation-promoting electric remodeling. This study assessed potential underlying signal transduction.… (More)
- Brett Burstein, Philippe Comtois, +4 authors Stanley Nattel
- Circulation research
- 2009
RATIONALE
Although connexin changes are important for the ventricular arrhythmic substrate in congestive heart failure (CHF), connexin alterations during CHF-related atrial arrhythmogenic remodeling… (More)
- Brett Burstein, Xiao-yan Qi, Yung-Hsin Yeh, Angelino Calderone, Stanley Nattel
- Cardiovascular research
- 2007
OBJECTIVE
Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling, contributing to the progressive nature of the arrhythmia. Ventricular dysfunction due to a rapid response… (More)
- Akiko Shiroshita-Takeshita, Bianca J. J. M. Brundel, +4 authors Stanley Nattel
- Cardiovascular research
- 2007
BACKGROUND
Congestive heart failure (CHF) is a common cause of atrial fibrillation (AF). Oxidative stress and inflammation (profibrotic) and peroxisome proliferator-activated receptor-alpha… (More)
- Yung-Hsin Yeh, Brett Burstein, +6 authors Stanley Nattel
- Circulation
- 2009
BACKGROUND
Sinoatrial node (SAN) dysfunction is frequently associated with atrial tachyarrhythmias (ATs). Abnormalities in SAN pacemaker function after termination of ATs can cause syncope and… (More)
- Brett Burstein, Stanley Nattel
- Journal of cardiovascular pharmacology
- 2008
Atrial fibrillation (AF) is the most common clinically encountered arrhythmia. Conventional pharmacological antiarrhythmic approaches suffer from poor efficacy and risk of serious complications,… (More)
- Brett Burstein, Ange Maguy, +7 authors Stanley Nattel
- The Journal of pharmacology and experimental…
- 2007
Resveratrol (RES; trans-3,5,4'-trihydroxystilbene) has been shown to improve health and slow the progression of disease in various models. Several cardioprotective mechanisms have been identified… (More)