Brett A. Freedman

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Degeneration of the intervertebral disc (IVD) represents a significant musculoskeletal disease burden. Although spinal fusion has some efficacy in pain management, spine biomechanics is ultimately compromised. In addition, there is inherent limitation of hardware-based IVD replacement prostheses, which underscores the importance of biological approaches to(More)
OBJECTIVE We retrospectively reviewed the results of 100 consecutive transforaminal lumbar interbody fusions (TLIFs) performed at one institution. The preoperative diagnoses included degenerative disk disease (55), spondylolisthesis (41; 22 isthmic, 19 degenerative), and degenerative adult scoliosis (4). There were 64 single-level, 33 two-level, 2(More)
BACKGROUND Arthroscopic debridement is the standard of care for the treatment of acetabular labral tears. The Short Form-36 has not been used to measure hip arthroscopy outcomes, and the impact of disability status on hip arthroscopy outcomes has not been reported. HYPOTHESIS Short Form-36 subscale scores will demonstrate good correlation with the(More)
Low-energy wrist (distal radius) fractures are hallmarks of osteoporosis. Prompt diagnosis and treatment of osteoporosis reduce refracture rates. We retrospectively determined the type and frequency of osteoporosis-related interventions rendered to patients 50 years and older in the year after a wrist fragility fracture. In addition, we compared the rates(More)
STUDY DESIGN A biomechanical study of 2 fixation techniques for lumbosacral fixation. OBJECTIVE To evaluate 2 techniques, one using S1 screws combined with bicortical, bitriangulated (BCBT) S2 screws, and the other using S1 screws combined with iliac screws. SUMMARY OF BACKGROUND DATA Common to the 2 techniques of sacral-pelvic fixation is S1 pedicle(More)
Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is a leading cause of viral encephalitis in Europe and Asia. Dendritic cells (DCs), as early cellular targets of infection, provide an opportunity for flaviviruses to inhibit innate and adaptive immune responses. Flaviviruses modulate DC function, but the mechanisms underpinning this(More)
Kummel disease is the eponym for avascular necrosis of the vertebral body after a vertebral compression fracture. As our population ages, the prevalence of osteoporosis, its most common fragility fracture (vertebral compression fracture), and Kummel disease will increase. The purpose of this article is to report a prototypical case with complete(More)
Yamoa (ground bark of Funtumia elastica tree) is marketed and sold as a dietary supplement with anecdotal therapeutic effects in the treatment of asthma and hay fever. We determined that Yamoa and Yamoa-derived polysaccharides affected innate immunity, in part, by priming gammadelta T cells. Gene expression patterns in purified bovine gammadelta T cells and(More)
BACKGROUND Enchondromas originating in the epiphyses of long bones are rare. The purpose of the present study was to evaluate the prevalence as well as the radiographic and clinical characteristics of epiphyseal enchondromas among patients who had been referred to the Armed Forces Institute of Pathology and Walter Reed Army Medical Center. METHODS We(More)
PURPOSE To assess the intraobserver reliability and prognostic value of magnetic resonance arthrography (MRA) on the basis of postoperative outcome measures following arthroscopic acetabular labral debridement (partial limbectomy). METHODS Between January 1999 and November 2000, 24 patients (13 females, 11 males) with an average age of 37.1 years (range,(More)