Breno A. Falcao

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Oral mucositis is a frequent side-effect of cancer therapy. A definitive method of prophylaxis or treatment is not yet available. As pentoxifylline (PTX) and thalidomide (TLD) have been shown to inhibit cytokine synthesis, we studied the effects of these cytokine inhibitors in an experimental oral mucositis model. Oral mucositis was induced in Golden(More)
AIMS We aimed to evaluate if the co-localisation of calcium and necrosis in intravascular ultrasound virtual histology (IVUS-VH) is due to artefact, and whether this effect can be mathematically estimated. METHODS AND RESULTS We hypothesised that, in case calcium induces an artefactual coding of necrosis, any addition in calcium content would generate an(More)
Generally, restrictive cardiomyopathy due to desmin deposition is characterized by restriction to ventricular diastolic filling and different degrees of atrioventricular block (AVB). In this report, we describe the pathological changes of the cardiac conduction system related to AVB. The sinus node, the compact node, and the penetrating bundle (bundle of(More)
Virtual Histology (IVUS-VH) is an image modality, derived from intravascular ultrasound (IVUS), which allows the identification of atheromatous components, providing a frame-by-frame tissue classification into four classes: Fibrotic Tissue, Fibro-Fatty Tissue, Necrotic-Core and Dense Calcium. According to current pathology consensus, intra-plaque spatial(More)
BACKGROUND The aim of this study is to present a new methodology for three-dimensional (3D) reconstruction of coronary arteries and plaque morphology using Computed Tomography Angiography (CTA). METHODS The methodology is summarized in six stages: 1) pre-processing of the initial raw images, 2) rough estimation of the lumen and outer vessel wall borders(More)
Telemedicine is an innovative tool in the setting of ST-elevation myocardial infarction (STEMI), because it addresses the greatest challenge-delivering optimal reperfusion therapies in a timely manner. Telemedicine targets delays related to geography, distance, and stated prehospital systems of care. Integration of telemedicine into prehospital STEMI(More)
AIMS While the atherosclerotic plaque volume can be manually quantified in coronary computed tomography angiography (CTA) it is impractical for clinical routine use. Several anatomical scores have been developed as surrogates for overall atherosclerotic burden in coronary CTA and even proven to be highly predictive for future adverse events. However, they(More)
OBJECTIVES To utilize telemedicine as a foundation platform for creating population-based STEMI networks. BACKGROUND Disparate acute myocardial infarction (AMI) management occurs in developed and developing countries on account of differences in infrastructure resources. As a result, developed countries utilize primary percutaneous coronary intervention(More)
BACKGROUND The diagnostic accuracy of 64-slice MDCT in comparison with IVUS has been poorly described and is mainly restricted to reports analyzing segments with documented atherosclerotic plaques. OBJECTIVES We compared 64-slice multidetector computed tomography (MDCT) with gray scale intravascular ultrasound (IVUS) for the evaluation of coronary lumen(More)
RESULTS For deferred lesions, the risk of MACE had significant inverse relationship with FFR (adjusted hazard ratio [aHR], 1.06; 95% confidence interval [CI], 1.05 1.08; P<0.001). However, this relationship was not observed in revascularized lesions (aHR, 1.00; 95% CI, 0.99 1.02; P1⁄40.69). For lesions with FFR of 0.76, the risk of MACE was not(More)