Interested in how molecular dynamics simulations can improve rational drug discovery, particularly at G protein-coupled receptors (GPCRs), the target of over one-third of current clinical drugs. Specifically, what are the structural and dynamic mechanisms governing positive allosteric modulation, biased signalling, and selectivity between closely related… (More)
For a wireless sensor network (WSN) to operate successfully in an application of detecting a mobile intruder, the sensor's sensing of the intruder and the communication between the tasking sensor(s) and the base station should be jointly considered for effective intrusion detection. Most related work either treats the two tasks separately or considers both… (More)
Network connectivity, as a fundamental issue in a wireless sensor network(WSN), has been receiving considerable attention during the past decade. Most works focused on how to maintain full connectivity while conserving network resources. However, full connectivity is actually a sufficient but not necessary condition for many WSNs to communicate and function… (More)
Smock for their valuable advice at an early stage in this project. A number of other Abt Associates staff contributed invaluable assistance, including Ozan Jaquette, Chris Hamilton, Daniel Weinberg, and Denise Young. All interpretations in this report are our own and do not necessarily reflect the views of the U.S. Department of Heath and Human Services.
The M2 muscarinic receptor is the prototypic model of allostery in GPCRs, yet the molecular and the supramolecular determinants of such effects are unknown. Monomers and oligomers of the M2 muscarinic receptor therefore have been compared to identify those allosteric properties that are gained in oligomers. Allosteric interactions were monitored by means of… (More)
Network connectivity is a critical property that provides communication foundation for most wireless sensor network (WSN) applications to operate successfully. Existing results on the WSN connectivity analysis are primarily based on a uniform distribution of sensors in a bounded field of interest. However, the sensor distribution can be non-uniform in… (More)