Brenda MacGibbon

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A matched case-control study was undertaken to assess the relative risk associated with known and suspected risk factors of squamous cell carcinoma of the skin among patients in the Montreal region. Three hundred eleven cases histologically diagnosed in 1977 and 1978 in 12 hospitals and meeting strict definition criteria were identified. With the exception(More)
BACKGROUND Up to 50% of adverse events that occur in hospitals are preventable. Language barriers and disabilities that affect communication have been shown to decrease quality of care. We sought to assess whether communication problems are associated with an increased risk of preventable adverse events. METHODS We randomly selected 20 general hospitals(More)
Long-term exposure to manganese (Mn) can induce neurotoxic effects including neuromotor, neurocognitive and neuropsychiatric effects, but there is a great interpersonal variability in the occurrence of these effects. It has recently been suggested that blood Mn (MnB) may interact with alcohol use disorders, accentuating neuropsychiatric symptoms. The(More)
A nonparametric wavelet based estimator is proposed for the location of a change-point in an otherwise smooth hazard function under noninformative random right censoring. The proposed estimator is based on wavelet coefficients differences via an appropriate parametrization of the time-frequency plane. The study of the estimator is facilitated by the strong(More)
To quantify prognosis in patients with end-stage renal disease, we evaluated pretreatment clinical state and ascertained the outcome of all 220 patients who began therapy at two hospitals from 1970 to 1975. Each of three pretreatment characteristics made a statistically significant independent contribution to the relative risk of death: age (relative risk(More)
PURPOSE Obesity, a major health issue, is also an important risk factor for infections. Evidence demonstrates that excess weight affects the disposition of antibiotics but little work has been done to explore if this results in antibiotic treatment failure (ATF). ATF has serious adverse health outcomes and may increase treatment resistance. Given that obese(More)
One of the main advantages of the discrete wavelet representation is the near-optimal estimation of signals corrupted with noise. After the seminal work of De Vore and Lucier (1992) and Donoho and Johnstone (1995), new techniques for choosing appropriate threshold and/or shrinkage functions have recently been explored by Bayesian and likelihood methods.(More)
The aim of this study was: (1) To determine the minimum number of characteristics necessary to discriminate between postural tremor recorded in control subjects (CO), in subjects exposed to manganese (MN), and in patients with Parkinson's disease (PD), and (2) to examine the continuum of changes between the three groups examined. Workers previously exposed(More)